Currently, there is no standardised process for monitoring and evaluation of nature-based flood defenses pilots in Dutch rivers and floodplains. Thus, piloted technologies cannot be compared fairly with other nature-based flood defense technologies and conventional solutions. This study developed such a process by way of a monitoring and evaluation framework, using a research-by-design approach. This monitoring and evaluation framework is incorporated into a knowledge base that was developed in parallel to store the results of monitoring and evaluating and to effectively share knowledge about each pilot for future reference. The primary intended users of the knowledge base are researchers, therefore requirements were elicited via interviews with matter experts. Findings from the interviews, combined with literature review, formed the basis of design and development for the monitoring and evaluation framework and knowledge base. A second round of interviews was held for iterative improvements of this design via feedback and subsequent revision. In total, three design-feedback iterations were done. The last provided validation results of the improved solution. The main findings indicate that a knowledge base approach has merit and it is suggested that Rijkswaterstaat adopt and improve this solution as a template within their innovation process. The innovation process at Rijkswaterstaat is being developed right now and has incorporated evaluation of pilots. Additional results are a large number of possible avenues for further development and future research.