In this paper, the design of a specific case study of a foyer space is concerned in healthcare facility. The design task of a healthcare facility in architectural perspective is one of the most challenging tasks in the architectural design field since it involves different spaces that have unique requirements. Specifically, a foyer space has been considered as a gathering area that answers people’s needs and expectations. The study shows an application of computational intelligence for a skylight design in foyer space. For this reason, objective functions are considered to minimize skylight cost and to maximize the daylight performance of the interior space. Multi-Objective Self-Adaptive Ensemble Differential Evolution Algorithm and Non-Dominated Sorting Genetic Algorithm-II are proposed to tackle this complex problem. According to results, jE_DEMO algorithm presents satisfactory solutions as well as NSGA-II.