The development of cellular microenvironments suitable for neural tissue engineering purposes involves a plethora of research fields ranging from cell biology to biochemistry, neurosciences, physics, nanotechnology, mechanobiology. In the last two decades, this multi-disciplinary activity has led to the emergence of numerous strategies to create architectures capable of reproducing the topological, biochemical and mechanical properties of the extracellular matrix present in the central (CNS) and peripheral nervous system (PNS). Some of these approaches have succeeded in inducing the functional recovery of damaged areas in the CNS and the PNS to address the current lack of effective medical treatments for this type of injury. In this review, we analyze recent developments in the realization of two-dimensional and three-dimensional neuronal scaffolds following either top-down or bottom-up approaches. After providing an overview of the different fabrication techniques employed for tailoring the biomaterials, we draw on specific examples to describe the major features of the developed approaches. We then conclude with prospective proof of concept studies on guiding scaffolds and regenerative models on macro-scale brain implants targeting neural regeneration.@en

Superconducting Nanowire Single Photon Detectors (SNSPDs) based on Nb0.15Re0.85 disordered nanowires are developed. The devices have a meander structure of wires 50 - 100 nm wide and cover a circular detection area with a diameter of about 10-16 μm. The main figures of merit of the detectors are extracted from a flood illumination process at 2.8 K, featuring a saturated internal efficiency up to λ = 1301 nm, recovery times between about 8 and 19 ns, and a jitter of about 35 ps. These results confirm that Nb0.15Re0.85 is a promising candidate for the realization of fast SNSPDs, as recently suggested. @en