Introduction:Timely personalized treatment of functional decline depends on early ambulant identification of persons at risk. Regularity of daily body acceleration, quantified by sample entropy (SampEn), is associated with fall risk and is a potential proxy for functional (biopsychosocial) resilience.
Objective: This cross-sectional study associates SampEn of daily life accelerometry with physical (short physical performance battery, SPPB [0 12]) and cognitive functioning (cognitive impairment test, 6 CIT [0-28]).Method: Data was provided from the HIPCARE cohort of 51 community-dwelling adults [81 (75 – 89)] after femur fracture. The SPPB, CIT, and 7 days accelerometry were recorded at three months follow-up after hip surgery. The mean SampEn for different activities was compared between patients with low (<4), moderate (4-9), and high (>9) SPPB and between low (<8) and high (>7) CIT with a significance of p≤0.05Results: Moderate SPPB scores had more regularity (lower SampEn) in complete daily life acceleration signals and during stair-walking than the high SPPB group. In addition, the cognitive impaired group (i.e., high CIT) had more regularity (lower SampEn) than the healthy group during cycling and sitting activities.Discussion and conclusions: More regular accelerations indicate the development of limited physical performance and deterioration of cognitive functions. The findings advocate that acceleration entropy in daily life activities is a promising proxy for physical and mental (biopsychological) functions. A large-scale longitudinal study is needed to examine the potential added value of daily acceleration for the early detection of biopsychosocial functioning.