YT

Y.I. Tepeli

6 records found

The shift to precision medicine in cancer focuses on providing therapies targeting vulnerabilities of each individual patient tumor. This approach involves identifying cancer subtypes and discovering targets, such as genetic interactions, to treat patients who lack effective ther ...
Motivation

Anti-cancer therapies based on synthetic lethality (SL) exploit tumour vulnerabilities for treatment with reduced side effects, by targeting a gene that is jointly essential with another whose function is lost. Computational prediction is key to expedite SL sc ...
Motivation
Synthetic lethality (SL) between two genes occurs when simultaneous loss of function leads to cell death. This holds great promise for developing anti-cancer therapeutics that target synthetic lethal pairs of endogenously disrupted genes. Identifying novel SL relat ...