Variable steering systems have the ability to change the ratio between the steering wheel and the front wheels while driving. These adjustable steering systems have led to an improvement in traffic and road safety and decrease in driver’s workload. A previous study concludes that driver steering behaviour is significantly dependent on vehicle speed and road curvature (number and sharpness of bends). Interestingly, variable steering ratio systems often depend on speed but not on road curvature. Variable steering ratio dependent on road curvature possibly influences driving behaviour and might be desirable for safety and driver acceptance. The goal of this research is to investigate driver acceptance and driving behaviour for two separate steering ratios (1:12 and 1:40) and two different road profiles (i.e. specific curvatures straight highway and curvy country road) at a constant speed. We hypothesize that on a curvy country road low steering ratio (1:12) leads to higher safety margins and subjective ratings, whereas on a straight highway a high steering ratio (1:40) leads to higher safety margins and subjective ratings. Therefore we conducted a within-subject driving experiment (N=24) in a fixed-based passenger vehicle simulator at constant speed. The results show that on a country road a vehicle with a low steering ratio increases time-to-line- crossing (TLC) safety margins and increases self-reported subjective ratings compared to the high steering ratio setting. Likewise, on a highway, a vehicle with a high steering ratio leads to higher safety margins and comfort rating compared to a low steering ratio. Thereby it can be concluded that steering ratio variable to the road profile improves safety and acceptance. These results provide promising evidence to make steering systems adaptable to road profile (e.g. steer-by-wire and active rear wheel steering).