GG

G. Giordano

118 records found

Agricultural production of annual crops is often hampered by annual weeds, which compete with planted crops and persist through the collection of dormant seeds in the soil called the weed seed bank. Conventional weed management relies heavily on chemical herbicides, which are not ...
Agent-based models of opinion formation are becoming increasingly complex, because of their size and of the embedding of several individual psychological traits of the agents, aimed at realistically capturing the multifaceted aspects of social interaction. Therefore, the characte ...
Fibromyalgia (FM) is a central disorder characterized by chronic pain, fatigue, insomnia, depression, and other minor symptoms. Knowledge about pathogenesis is lacking, diagnosis difficult, clinical approach puzzling, and patient management disappointing. We conducted a theoretic ...
When agent-based models are developed to capture opinion formation in large-scale populations, the opinion update equations often need to embed several complex psychological traits. The resulting models are more realistic, but also challenging to assess analytically, and hence nu ...
In 2022, worldwide mpox outbreaks have called attention to mpox virus infection and treatment opportunities using the drugs cidofovir and tecovirimat, which target different stages of in-host viral proliferation, respectively production and shedding. We propose a new model of in- ...
We consider a class of biological networks where the nodes are associated with first-order linear dynamics and their interactions, which can be either activating or inhibitory, are modelled by nonlinear Michaelis–Menten functions (i.e., Hill functions with unitary Hill coefficien ...
We propose an agent-based opinion formation model characterised by a two-fold novelty. First, we realistically assume that each agent cannot measure the opinion of its neighbours about a given statement with infinite resolution and accuracy, and hence it can only perceive the opi ...
Recombinases are site-specific proteins found in nature that are capable of rearranging DNA. This function has made them promising gene editing tools in synthetic biology, as well as key elements in complex artificial gene circuits implementing Boolean logic. However, since DNA r ...
The interaction of phase-separating systems with chemical reactions is of great interest in various contexts, from biology to material science. In biology, phase separation is thought to be the driving force behind the formation of biomolecular condensates, i.e., organelles witho ...
Early detection of the emergence of a new variant of concern (VoC) is essential to develop strategies that contain epidemic outbreaks. For example, knowing in which region a VoC starts spreading enables prompt actions to circumscribe the geographical area where the new variant ca ...
Mal de Debarquement Syndrome (MdDS) is a puzzling central vestibular disorder characterized by a long-lasting perception of oscillatory postural instability that may occur after sea travels or flights. We have postulated that MdDS originates from the post-disembarking persistence ...
In this article, we propose a dynamic augmentation scheme for the asymptotic solution of the nonlinear algebraic loops arising in well-known input saturated feedbacks typically designed by solving linear matrix inequalities. We prove that the existing approach based on dynamic au ...
We formulate a control problem for positive compartmental systems formed by nodes (buffers) and arcs (flows). Our main result is that, on a finite horizon, we can solve the Pontryagin equations in one shot without resorting to trial and error via shooting. As expected, the soluti ...
When facing the global health threat posed by an infectious disease, predictive mathematical models are crucial not only to understand and forecast the epidemic evolution, but also to plan effective control strategies that contrast the disease and its spread in the population. Th ...
Comparing model predictions with real data is crucial to improve and validate a model. For opinion formation models, validation based on real data is uncommon and difficult to obtain, also due to the lack of systematic approaches for a meaningful comparison. We introduce a framew ...
Engineered genetic circuits with tailored functions that mimic how cells process information in changing environments (e.g. cell fate decision, chemotaxis, immune response) have great applications in biomedicine and synthetic biology. Although there is a lot of progress toward th ...
We proposed network-decentralized control strategies, in which each actuator can exclusively rely on local information, without knowing the network topology and the external input, ensuring that the flow asymptotically converges to the optimal one with respect to the p -norm. For ...
Starting from a symmetric state-feedback solution ensuring α-exponential convergence in an ellipsoidal sublevel set, with asymmetric saturation and single-input linear plants, we propose a novel asymmetric scheduled extension preserving the original symmetric solution in that ...
Fibromyalgia (FM) is an unsolved central pain processing disturbance. We aim to provide a unifying model for FM pathogenesis based on a loop network involving thalamocortical regions, i.e., the ventroposterior lateral thalamus (VPL), the somatosensory cortex (SC), and the thalami ...