From a global perspective, the building industry is one of the significant factors of environmental impact on the planet. Related activities in this industry refer to 40% of total carbon emissions; 28% of this value accounts for building operations, while the remaining 12% represents the manufacturing of new construction materials. Studies have revealed that 90% of construction waste comes from demolition (Ahn et al., 2022). Wood as a construction material is an uprising in the building practice due to its carbon storage capabilities and prefabricated possibilities (Gong, 2021). Prefabricated timber constructions can benefit rural Colombia's social reconstruction with the help of digital fabrication technologies. Likewise, this method could bring better performance of materials and its End of Life (EOL) (Ahn et al., 2022). Nevertheless, research has identified wood-to-wood timber connections as a gap in the academia to tackle better design, manufacture, assembly, and deconstruction (DfMA + D) in the field (Mehra et al., 2021). The following study aims to investigate the application of CNC technologies to fabricate novel and affordable wood joinery connection solutions for the construction of rural housing in Colombia. This research emphasizes the cooperation of the wood material to moisture fluctuation, with the aim of introducing a more sustainable and efficient assembly method.