This research investigates the potential of biobased and vapour-open construction principles with the objective to increase health and well-being in residential architecture. Conventional building materials and airtight construction methods often contribute to poor indoor air quality, leading to issues such as the Sick Building Syndrome (SBS). By contrast, biobased materials, and vapour-open façade designs allow for natural moisture regulation, improved air circulation, and reduced indoor pollutants. Through literature review, a case study, most notably the Hemphouse project, and performance simulations, this study examines the technical feasibility and environmental benefits of these sustainable building practices. Findings suggest that vapour-open structures can passively manage indoor humidity levels, reduce mould risks, and enhance overall occupant comfort. Additionally, the integration of locally sourced, renewable materials aligns with climate-conscious design strategies, supporting both ecological sustainability and healthier living environments here in The Netherlands. The results advocate for a shift in residential architecture, promoting breathable and nature-inspired design solutions as viable alternatives to conventional building methods.