P.Q. van der Meulen
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12 records found
1
We consider the scenario of finding the transfer function of an aberrating layer in front of a receiving ultrasound (US) array, assuming a separate non-aberrated transmit source. We propose a method for blindly estimating this transfer function without exact knowledge of the ultrasound sources or acoustic contrast image, and without directly measuring the transfer function using a separate controlled calibration experiment. Instead, the measurement data of many unknown random images is collected, such as from blood flow, and its second-order statistics are exploited. A measurement model is formulated that explicitly defines the layer's transfer function. A covariance domain problem is then defined to eliminate the image variable, and it is solved for the layer's transfer function using manifold-based optimization. The proposed approach and calibration algorithm are evaluated on a range of challenging and realistic simulations using the k-Wave toolbox. Our results show that, given a sufficiently efficient parameterization of the layer's transfer function, and by jointly estimating the transfer function at multiple frequencies, the proposed algorithm is able to obtain an accurate estimate. Subsequent simulated imaging experiments using the obtained transfer function also show increased imaging performance in various aberrating layers, including a skull layer.
Photoacoustic (PA) imaging can be used to monitor flowing blood inside the microvascular and capillary bed. Ultrasound speckle decorrelation based velocimetry imaging was previously shown to accurately estimate blood flow velocity in mouse brain (micro-)vasculature. Translating this method to photoacoustic imaging will allow simultaneous imaging of flow velocity and extracting functional parameters like blood oxygenation. In this study, we use a pulsed laser diode and a quantitative method based on normalized first order field autocorrelation function of PA field fluctuations to estimate flow velocities in an ink tube phantom and in the microvasculature of the chorioallantoic membrane of a chicken embryo. We demonstrate how the decorrelation time of signals acquired over frames are related to the flow speed and show that the PA flow analysis based on this approach is an angle independent flow velocity imaging method.
We consider a model-based ultrasound imaging scenario using a single transducer with a coding mask, and assume that the pulse-echo model is erroneously estimated, resulting in decreased imaging performance. Although the pulse-echo Green's function to each pixel has to be measured to obtain a good model, typically only forward-field measurements are obtained for better SNR, from which the pulse-echo Green's functions are estimated. However, if the transducer's receive transfer function is different from the transmit transfer function, the forward-field measurements do not incorporate the receive transfer function, resulting in an incorrect pulse-echo model. We propose two calibration techniques that start with this erroneous model, and update it using pulse-echo measurements. In the first technique we assume the calibration phantom is known a priori, whereas in the second technique we use multiple random calibration phantoms of which only the second-order statistics are assumed to be known beforehand. Both methods are able to significantly improve the pulse-echo model, strongly improving imaging performance. Our simulation results show that the first technique works best, since there is no uncertainty about the calibration image, whereas the blind calibration technique requires no exact knowledge of the calibration phantom, making it robust to positioning or manufacturing errors.
We present a form of acoustic microscopy, called Structured Ultrasound Microscopy (SUM). It creates a volumetric image by recording reflected echoes of ultrasound waves with a structured phase front using a moving single-element transducer and computational reconstruction. A priori knowledge of the acoustic field produced by the single element allows us to relate the received echoes to a 3D scatter map within the acoustic beam itself, leading to an isotropic resolution at all depths. An aberration mask in front of the acoustic element imposes the phase structure, broadening the beam and breaking the spatial coherence between different voxels at equal acoustic propagation delay, increasing the uniqueness of the reconstruction. By translating the transducer across the 3D volume, we synthetically enlarge the imaging aperture by using multiple overlapping and spatially sparsely sampled measurements to solve for the entire image. In this paper, we explain the SUM technique and demonstrate microscopic imaging at 20 MHz of a 2.3 × 2.3 × 1.2 mm object in water, with an isotropic resolution below 100 μm. The proposed approach allows for wide-field 3D imaging at isotropic microscopic resolution using a small unfocused ultrasound sensor and multiple spatially sparsely sampled measurements. This technique may find applications in many other fields where space is constrained, device simplicity is desired, and wide-field isotropic high-resolution imaging is required.
High quality three dimensional ultrasound imaging is typically attained by increasing the amount of sensors, resulting in complex hardware. Compressing measurements before sensing addresses this problem, and could enable new clinical applications. We have developed an analogue compression technique, by positioning a plastic coding mask in front of the aperture, which distorts the ultrasound field by inducing varying local echo delays. This results in a compression of the spatial ultrasound field across the sensor surface, while retaining sufficient information for 3D imaging. Using only a single sensor, complementary measurements can be obtained by rotation of the sensor and the mask to increase the conditioning of the reconstruction problem. In this work, we study a method to optimize the shape of the coding mask. To this end, we define an approximate signal model that captures the ultrasound response of the mask, and use it to pose mask shape optimization as a sensor selection problem. We solve it by relaxing it to a convex problem, as well as by using a greedy selection method. Our simulation results show that these approaches are able to outperform the random design strategy, in particular when mask rotations are included in the problem.