Carbon dioxide (CO₂) injection has been widely used in conventional reservoirs for enhanced oil recovery and CO₂ sequestration. Nevertheless, the effectiveness of CO₂ injection in tight reservoirs is limited due to diagenetic processes that impact displacement efficiency. This research work assesses the performance of CO₂ injection in tight reservoirs and evaluates oil mobilization and fluid distribution within the rock pore systems. A set of experiments, including routine core analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), and mercury injection capillary pressure (MICP), was performed on Scioto sandstone. Three core-flooding runs were conducted to evaluate oil recovery of different injection schemes, including tertiary miscible CO₂ injection, secondary immiscible CO₂ injection, and secondary miscible CO₂ injection. A nuclear magnetic resonance (NMR) spectrometer was utilized to evaluate the fluid distribution in pre- and postflooding schemes. Results show that secondary miscible CO₂ injection provided the highest displacement efficiency (E_d) of 88%, with oil mobilized from both micro- and macropore systems, leading to the highest oil recovery of 93% original oil in place (OOIP). Tertiary miscible CO₂ injection had E_d of 67%, providing an ultimate oil recovery of 79% OOIP mostly from the macropore system. Limited contribution of micropores during the tertiary miscible CO₂ injection is attributed to the increased water content as a result of previously conducted secondary water flooding. Secondary immiscible CO₂ injection showed the least oil recovery among the injection schemes of 68% OOIP, which is attributed to the unstable displacement, as indicated by E_d of 52%. The efficiency of pore fluid displacement was determined through NMR analyses, and the findings are in line with the displacement efficiency values obtained from core-flood experiments, with a strong positive correlation. This finding is a promising strategy for determining a suitable CO₂ injection scheme in tight rocks for oil recovery and CO₂ storage.