Janina Preissler

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Journal article (1)

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A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H

Journal article (2022) - Holly A. Reeve Reeve (author) , Jake Nicholson Nicholson (author) , Kylie A. Vincent Vincent (author) , Farieha Altaf Altaf (author) , Thomas H. Lonsdale Lonsdale (author) , Janina Preissler Preissler (author) , Lars Lauterbach Lauterbach (author) , Oliver Lenz Lenz (author) , Silke Leimkühler Leimkühler (author) , F. Hollmann Hollmann (author) , C.E. Paul Paul (author)

We demonstrate a recycling system for synthetic nicotinamide cofactor analogues using a soluble hydrogenase with turnover number of >1000 for reduction of the cofactor analogues by H2. Coupling this system to an ene reductase, we show quantitative conversion of N-ethylmaleimid ...