In recent years, numerous public and private organizations have collaborated to address societal challenges through mission-driven innovation. Despite the many initiatives started with to tackle these challenges, many fail to achieve the impact they ought to deliver. Collaboration leaders frequently struggle to comprehend the complexity of their problem contexts deeply, hindering the development of effective solution strategies. Furthermore, the contexts and ecosystems of these mission-driven collaborations vary significantly. For instance, the shift to preventive healthcare presents different challenges compared to transitioning to a processing industry capable of managing periods of abundant renewable electrical energy. This study identifies various dimensions that can help delineate the complexity of these problems. These dimensions include convergent or divergent views on problems and solutions, ecosystem structure, stakeholder complexity, and stakeholder interdependence.