The aerospace industry’s push for faster, lighter, and more durable designs highlights the critical challenge of panel flutter in supersonic flight, a poorly understood phenomenon intensified by shock-wave/boundary-layer interactions (SWBLI). This study experimentally investigates the effects of static and dynamic panel deformations on shock-induced panel flutter at Mach 2.0, using open, closed, and ventilated cavity conditions. Results show that cavity closure significantly influences panel response, with the open cavity causing greater oscillations due to strong pressure waves entering it, causing resonance behaviour; closing the cavity seems to filter out this resonance behaviour. Additionally, temperature changes and wind tunnel confinement were identified as factors affecting panel and flow behaviour. The results underscore the importance of understanding experimental conditions to accurately interpret fluid-structure interactions in supersonic conditions.