This report focuses on the optimal utilization of commercial office real estate at Schiphol Amsterdam Airport to further contribute to the Mainport Strategy of the Netherlands. It is important to realize that the non-aeronautical activities play a crucial role for the business of the airport, especially considering factors such as a limit on the number of flight transfers per year and the increasing airport charges, that contribute negatively to the aviation business. This research emphasizes focuses on the emergent knowledge economy and how a functional program for office real estate at the airport can further contribute to the knowledge-intensive firms locating there. The literature review forms the base for the research which shows the existing Mainport strategy and Schiphol’s role, followed by an insight into the emergent knowledge economy and its potential for the airport location. Next, the empirical part of this research includes understanding the demands of the knowledge corporations at the airport, the strategies used by the office providers, and experts opinions to corroborate the findings from the demand and supply side. Thus, using this triangulation scheme, strategic recommendations are made for an optimal utilization of the office space to Schiphol Real Estate. This research is highly pertinent not only to the real estate department at Schiphol and other knowledge corporations who are looking to (re)locate in the airport vicinity, and also for other airports around the world to provide appropriate real estate for the commercial office spaces.