In this research, insight is gained into the impacts of truck platooning on traffic performance and safety at motorway on-ramps in mixed traffic using microscopic simulation. Thereby different platooning strategies and platoon configurations are considered, that for instance differ in desired platoon inter-vehicle gaps and platoon sizes. The effects are considered for a broad range of traffic intensities and penetration rates of equipped trucks. Merging problems are observed, but these can be solved if the platoon members yield to create a gap for merging vehicles.