The scour protection layers are usually installed around the monopiles to prevent the formation of scour hole. While extensive studies have been performed on the effectiveness of scour protection layer as mitigation measure, no study to date has been found to quantify the influence of scour protection layer on the lateral response of monopiles. In this study, centrifuge tests and numerical analyses were performed to examine explicitly the influence of the scour protection layer on the monopile response under lateral load in sand. It was found that a scour protection layer with a diameter of 5 times the diameter of the monopile (5D) and equivalent surcharge pressure of 15 kPa can increase the foundation lateral capacity by more than 30% and significantly decrease the accumulation of deflection by more than 100% in dense sand. Numerical analyses suggested that the beneficial contribution is attributed to the densification of sand and the increase of effective stress around the pile, which increased the stiffness and ultimate resistance of the soil reaction curve (i.e., p-y curve). Numerical parametric studies suggested that the beneficial effect of scour protection layer is also applicable to monopile in loose sand and by considering the contribution of the scour protection layer, the embedment length of the monopile can be reduced by 10%.