The Iberian Pyrite Belt (IPB), a historically mined Volcanogenic Massive Sulfide (VMS) region in southern Spain and Portugal, suffers from severe environmental degradation due to unregulated mine closures. This thesis develops a scalable rehabilitation strategy for legacy mine waste in the IPB, using data and samples obtained from the inactive San Miguel mine site. The findings are expanded into broader recommendations for an arbitrarily chosen study area, addressing both active and inactive sites, and offering guidance for sustainable mine management in the IPB and similar mining regions worldwide. In doing so, a multidisciplinary methodology is applied, integrating geochemical analysis, ArcGIS-based spatial modelling, literature reviews, cost assessments, and a Social Life Cycle Assessment (S-LCA) to ensure a comprehensive evaluation of rehabilitation potential and impact in the study area. Heavy metal contamination, primarily arsenic (As), copper (Cu), and lead (Pb), was identified as a major concern, with all sampled materials from San Miguel exceeding regulatory thresholds. The pollution in this area is mainly linked to acid mine drainage (AMD) and mobilization of heavy metals from historic mine waste and slag deposit. Geo-spatial extrapolation using Sentinel-2 imagery enabled mapping of contamination across the study area, justifying areawide remediation measures. A multifaceted rehabilitation strategy is proposed for the study area, combining physical and biological treatments to address AMD and heavy metal pollution from the inactive mine sites. The proposed interventions include the installation of geo-membranes in historical mine ponds to prevent leachate migration,while Sulfate Reducing Bacteria (SRB), applied via Diffusion Active Reactive Permeable Barriers (DAPRB) systems, will treat AMD by neutralizing acidity and precipitating insoluble sulfide metal compounds. Phytostabilization, using metal tolerant native plants, will immobilize contaminants in soil, and revegetation will enhance slope stability and support ecosystem recovery. Together, these approaches address historical and present mining related pollution in the study without aiming to eliminate naturally occurring acid rock drainage (ARD), focusing instead on mitigating its mining induced intensification. The total estimated rehabilitation cost for the seven historical mine sites in the study area is approximately €25.2 million, with revegetation and geo-membrane installation being the most expensive components. A S-LCA was conducted to evaluate the socal and socio-economic impacts of legacy and ongoing mining activities, as well as the projected outcomes of the proposed rehabilitation efforts in the study area. The S-LCA shows that historical and active mining have disproportionately affected local residents, farmers, and municipalities in terms of health and environmental degradation.For instance, the study area is commonly referred to as the triangle of death, whereas it has the largest cancer mortality rate in all of Spain. Conversely, reclamation improves outcomes in those same domains, especially for communities closest to the intervention zone of the study area. Recommendations are also formulated for Zones 2–4, which include active and inactive mine sites. Inactive mines should adopt the study area plan with minimal adaptation. Active mines must incorporate early-phase AMD mitigation, proactive monitoring, and closure planning to prevent legacy pollution.