In this commentary, we describe the current state of the art of points of interest (POIs) as digital, spatial datasets, both in terms of their quality and affordings, and how they are used across research domains. We argue that good spatial coverage and high-quality POI features — especially POI category and temporality information — are key for creating reliable data. We list challenges in POI geolocation and spatial representation, data fidelity, and POI attributes, and address how these challenges may affect the results of geospatial analyses of the built environment for applications in public health, urban planning, sustainable development, mobility, community studies, and sociology. This commentary is intended to shed more light on the importance of POIs both as standalone spatial datasets and as input to geospatial analyses.