A. Psyllidis
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38 records found
1
Prenatal environmental exposures associated with ADHD diagnosis in children
A multicentre exposome analysis
Attention deficit hyperactivity disorder (ADHD) is one of the most diagnosed neurodevelopmental conditions. While its aetiology is primarily attributed to genetic factors, the complex interplay with environmental exposures remains poorly understood. We investigated the relationship between prenatal environmental exposures (excluding biomarkers) and ADHD, utilizing data from seven cohorts (n = 156,563 children) across Europe. A supervised machine learning model (Random Forest) was run at each cohort site to identify the environmental exposures most informative for classifying ADHD. The results were pooled by averaging variable importance ranks across cohorts and highest-ranking variables were then used in logistic regression to obtain interpretable associations. Finally, a random-effects meta -analysis with restricted maximum likelihood estimation was used to infer the associations across cohorts. Based on Random Forest, built and natural urban characteristics, air pollution, and maternal socioeconomic factors were selected as variables with the greatest predictive contribution to ADHD classification. Associations with built and natural urban characteristics and air pollution were not robust across cohorts and largely attenuated in fully adjusted models. Meta-analysis across cohorts showed increased odds of ADHD for maternal smoking during pregnancy (OR = 1.67, 95% CI: 1.31, 2.14, I2 = 65.5%) and low maternal education (OR = 1.62, 95% CI: 1.27, 2.07, I2 = 51.3%), with substantial heterogeneity. Our findings indicated that maternal smoking during pregnancy and low maternal education were associated with increased odds of ADHD diagnoses in children, suggesting the potential role of socioeconomic disparities. However, gene-environment correlation cannot be ruled out.
Transport-related social exclusion in Latin America
A multilingual scoping review of modal choice and travel behaviour
CTwalk
A tool for mapping potential inter-population encounters In X-minute neighborhoods
Population-specific factors of pedestrian accessibility
Bridging practitioner insights and accessibility metrics
Mobility Futures
Four scenarios for the Dutch mobility system in 2050
Children’s access to urban greenspace
A survey of factors and measures
Bridging or separating?
Co-accessibility as a measure of potential place-based encounters
“Eyes on the Street”
Estimating Natural Surveillance Along Amsterdam’s City Streets Using Street-Level Imagery
Recent evidence underscores the importance of greenspace exposure in promoting physical activity, and in having a positive impact on mental health and cognitive development. Accessibility has been identified to be the primary motivating factor when it comes to encouraging greenspace use and, correspondingly, exposure. Existing quantitative approaches to measuring greenspace accessibility predominantly focus on the areas surrounding home locations, often disregarding access from other settings such as schools or workplaces, exposures while on the move, and mobility differences among different population age groups. This article introduces a novel method to measure greenspace accessibility that considers access from different activity settings (i.e., homes, schools, and the commutes between them) for children and adolescents, while accounting for the dependency of human access on the road network. We use Amsterdam, Rotterdam, and The Hague in the Netherlands as case studies to illustrate the utility of our method. Compared to conventional measures of greenspace accessibility, we show that accounting for school and commuting settings, in addition to residences, captures previously untapped accessibility aspects for both children and adolescents. Our approach can be replicated in other cities worldwide, with the aspiration to provide planners and public health policy-makers with a methodological tool that can help in evaluating access and use of greenspaces when designing health-promoting interventions.
Is it safe to be attractive?
Disentangling the influence of streetscape features on the perceived safety and attractiveness of city streets
Early environmental quality and life-course mental health effects
The Equal-Life project
There is increasing evidence that a complex interplay of factors within environments in which children grows up, contributes to children’s suboptimal mental health and cognitive development. The concept of the life-course exposome helps to study the impact of the physical and social environment, including social inequities, on cognitive development and mental health over time.
Methods:
Equal-Life develops and tests combined exposures and their effects on children’s mental health and cognitive development. Data from eight birth-cohorts and three school studies (N = 240.000) linked to exposure data, will provide insights and policy guidance into aspects of physical and social exposures hitherto untapped, at different scale levels and timeframes, while accounting for social inequities. Reasoning from the outcome point of view, relevant stakeholders participate in the formulation and validation of research questions, and in the formulation of environmental hazards. Exposure assessment combines GIS-based environmental indicators with omics approaches and new data sources, forming the early-life exposome. Statistical tools integrate data at different spatial and temporal granularity and combine exploratory machine learning models with hypothesis-driven causal modeling.
Conclusions:
Equal-Life contributes to the development and utilization of the exposome concept by (1) integrating the internal, physical and social exposomes, (2) studying a distinct set of life-course effects on a child’s development and mental health (3) characterizing the child’s environment at different developmental stages and in different activity spaces, (4) looking at supportive environments for child development, rather than merely pollutants, and (5) combining physical, social indicators with novel effect markers and using new data sources describing child activity patterns and environments. ...
There is increasing evidence that a complex interplay of factors within environments in which children grows up, contributes to children’s suboptimal mental health and cognitive development. The concept of the life-course exposome helps to study the impact of the physical and social environment, including social inequities, on cognitive development and mental health over time.
Methods:
Equal-Life develops and tests combined exposures and their effects on children’s mental health and cognitive development. Data from eight birth-cohorts and three school studies (N = 240.000) linked to exposure data, will provide insights and policy guidance into aspects of physical and social exposures hitherto untapped, at different scale levels and timeframes, while accounting for social inequities. Reasoning from the outcome point of view, relevant stakeholders participate in the formulation and validation of research questions, and in the formulation of environmental hazards. Exposure assessment combines GIS-based environmental indicators with omics approaches and new data sources, forming the early-life exposome. Statistical tools integrate data at different spatial and temporal granularity and combine exploratory machine learning models with hypothesis-driven causal modeling.
Conclusions:
Equal-Life contributes to the development and utilization of the exposome concept by (1) integrating the internal, physical and social exposomes, (2) studying a distinct set of life-course effects on a child’s development and mental health (3) characterizing the child’s environment at different developmental stages and in different activity spaces, (4) looking at supportive environments for child development, rather than merely pollutants, and (5) combining physical, social indicators with novel effect markers and using new data sources describing child activity patterns and environments.