Ceiling fans offer a low-energy solution for improving thermal comfort in offices, yet their ability to provide collective comfort, serving multiple occupants, remains underexplored, especially when airflow is diffused by desk layouts.

This thesis examines whether office desks can diffuse ceiling fan-induced airflow and expand the comfort zone. A mixed-methods approach was used, combining CFD simulations, lab-based airspeed measurements, and human-subject experiments to assess airflow distribution and perceived comfort across multiple desk configurations and fan speeds.

Results show that desks redirect downward airflow horizontally, increasing airspeed at seated height (0.85m). While higher air speeds lowered thermal sensation votes, comfort levels did not increase. At 28°C and 49.2% RH, participants preferred an average airspeed of 0.49 m/s without group control. With group-selected fan speeds, preferences varied between 0.49–0.78 m/s, indicating diverse comfort needs.

The development of clinical imaging techniques significantly improves diagnostic accuracy and provides guidance for personalized treatment of individuals. However, every single imaging modality has its distinct drawbacks that cannot fully fulfil the diagnosis requirement. Thus, rational combination of different imaging modalities can achieve more comprehensive information of disease and in this way provide better personalized treatment strategy. The hybrid PET/MRI has drawn increasing attention since its first clinical application. Imaging probes play an essential role in achieving qualified figures with accurate information of diseases. The application of nanotechnology promotes the development of versatile molecular probes for PET/MRI technique. Though there is an emerging clinical requirement, only a small number of multimodal PET/MRI probes have been investigated in preclinical research. Thus, this review tries to thoroughly summarize the nano-sized PET/MRI probes on their design, preparation and biological application. By discussing the strength and limitations of these current available PET/MRI multimodal probes, this work aims to figure out the further research direction and promote the possible clinic translation of the novel PET/MRI probes.