Adaptive urban transformations employ landscape-based regional design as an integrative and multiscale design and planning approach for sustainable urban development. In this approach, natural and urban dynamics as derived from systems analysis set the pace and nature of adaptation. This chapter presents an initial strategy for adaptive urban transformation in the Pearl River Delta to illustrate the potential of landscape-based regional design as form of territorial governance that takes the natural and urban landscape as the basis to steer urban–rural transformative processes through a combination of sector activities towards more coordinated sustainable outcomes. The strategic spatial plan and subsequent implementation by means of pilot projects will focus on the potential of interlinked economic and ecological development at multiple scales. Together with the assessment of urban landscape growth over time and the evaluation of current spatial development projects in the region, several significant factors of future development have been identified, leading to an initial strategic vision and transformation perspectives for the PRD. This vision is based on the idea that the PRD will develop into China's Silicon Valley, with strongly developed and well-connected urban qualities, robust green–blue frameworks, cultural-historical assets connected to the region and water-sensitive socio-ecological inclusive urbanism.