Many desalination plants still struggle to control biological fouling in seawater reverse osmosis (SWRO) systems as there are no standard methods to monitor this type of fouling. Strategies to control biofouling in SWRO systems have been proposed such as antifouling coating and lowering biofouling potential in SWRO feedwater through pretreatment processes. Measuring biofouling potential in the pretreatment and SWRO feedwater has gained increased interest due to its direct link to biofouling. Moreover, this approach can be used as an early warning system allowing for taking corrective actions in the pretreatment processes to meet the required SWRO feedwater quality. This article presents the biofouling potential methods/tools developed for seawater, their applications to monitor and assess raw seawater, SWRO pretreatment and SWRO feedwater, and how these methods are employed to control SWRO biofouling membrane systems. The reported removal efficiency of biofouling potential during SWRO pretreatment processes was found to be low to moderate. Threshold values for biofouling limitation were then proposed based on several lab and plant studies. Research on biofouling potential has provided insight into SWRO pretreatment performance optimisation and biofouling control. Future research is anticipated to determine better pretreatment processes and to identify robust threshold values for mitigating biofouling in SWRO membranes.