The unprecedented speed and scale of urbanization in China calls for advanced planning and design strategies. This paper aims to explore a new pedagogical approach that cultivates morphological regional design studies to develop spatial strategies that acknowledge the complex and diverse urban landscapes of Chinese megaregions. Accordingly, the objective is to compare different morphological themes that form the basis for speculative gameboarding as a regional design methodology in the setting of academic planning and design studios. The paper evaluates a collection of outcomes from four years of collaboration between The Hong Kong Polytechnic University’s School of Design and the TU Delft’s Department of Urbanism. Here, gameboarding was used as a methodology to draft scenarios for large-scale spatial transformation in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA). Firstly, the paper explains the pedagogical trajectory of the studios along their three main phases — analysis, gameboarding, and evaluation. Secondly, it is investigated in how far the given morphological themes informed the design outcomes of the students. These outcomes are compared with regard to their spatial specificity as well as the radicalness of proposed transformations. Lastly, it is discussed if some of the themes are more suitable than others to respond to the socio-cultural and environmental specificities of the GBA. In six design studios, students worked on eight different morphological themes: pointillist, linear, strip, megablock, radial, ring, cross, and edge. It is found that redundancies exist between some of the themes, which suggests that the consolidation of themes might be worth exploring. Furthermore, the different context of the studios in the two universities seems to affect the role that gameboarding takes in the process. Overall, the teaching methodology has proven to generate a wide range of design strategies that point far beyond conventional spatial planning solutions. Speculative gameboarding with morphological themes is therefore a promising methodology that may be further enhanced and tested for other forms of stakeholder engagement.