Climate change and socioeconomic developments have led to highly stressed estuarine systems in which dissimilar and conflicting stakeholder interests can no longer be satisfied simultaneously, inevitably resulting in trade-offs. Since translating these stakeholder interests into quantifiable performance indicators is challenging, policy and decision-makers are often bound to qualitative trade-off assessments, potentially resulting in suboptimal system interventions. In this paper, we assess the well-known socioeconomic trade-off in estuaries worldwide: port accessibility versus freshwater availability. We consider the severely dry year of 2022 in the Rhine-Meuse Delta, for which we assess the effects of bed level change. To quantify the trade-off, we apply a general framework of performance indicators determined based on models that use the output of a validated hydrodynamic model, including salt transport. Port accessibility was quantified based on vessel waiting times, using a data-driven nautical traffic model. For the performance indicator of freshwater availability, we developed a metric that includes storage capacity. The method resulted in a trade-off curve showing improved freshwater availability and deteriorated port accessibility for decreasing bed level. This trade-off curve provides valuable insights into system interventions in a multidisciplinary setting, being an intuitive visualisation showcasing the (non-monetary) benefits and costs for different stakeholders with dissimilar interests. As the method could be expanded and applied further, this study aids quantitative policy and decision-making.