Under the exposome framework, this study examined the relationship between the urban physical environment and leisure-time physical activity during early midlife based on 394 participants (mean age: 37, range 34–40) from the FinnTwin12 cohort, residing in five major Finnish cities in 2020. We curated 145 urban physical exposures based on residential addresses and measured three outcomes: total leisure-time physical activity (total LTPA) and two sub-domains: leisure-time physical activity without commuting activity (LTPA) and commuting activity. K-prototypes clustering identified three urban clusters: “original city center,” “new city center,” and “suburban,” each with distinct environmental patterns. Regression models showed that participants in the “suburban” cluster had lower levels of total LTPA and LTPA compared to those in the “original city center” cluster, while we found null findings for commuting activity. Then, repeated regression models with a p-value threshold of 0.01 were used to initially select candidates. eXtreme Gradient Boosting models identified greenspaces and road characteristics as the top important factors influencing total LTPA, while pocket park and greenness were ranked as the top important factors influencing LTPA. The relationships were non-linear. There were thresholds for the count and size of pocket parks within 800 m walking distance and the modified soil adjusted vegetation index, determining whether they positively or negatively predict LTPA. Our findings suggested that the urban environment in Finnish cities was associated with leisure-time physical activity, which revealed new residential pattern and identified key exposures of road, pocket park, and greenness with non-linear effect, that can guide future policies.

Health implications of mobility during pregnancy entail a need to understand pregnant women's activity spaces. We present ActMAP, a framework for quantifying multiple aspects of activity spaces from distinct trips and stays derived from GPS data. We applied ActMAP to data from 238 pregnant women in Barcelona, Spain (2018–2020) and explored weekday, weekend and intraday associations between pregnancy trimester and activity spaces. Activities were more centred around the home later in pregnancy. However, the number of visited places and daily trips remained largely constant throughout pregnancy. By constructing activity spaces from individual trips and stays, ActMAP could provide a framework for GPS-based holistic assessments of mobility.