A miniaturized EHT platform for contractile tissue measurements
Milica Dostanic (TU Delft - Electronic Components, Technology and Materials)
Laura Windt (Leiden University Medical Center)
Jeroen Stein (Leiden University Medical Center)
Berend van Meer (Leiden University Medical Center)
Max Mastrangeli (TU Delft - Electronic Components, Technology and Materials)
Christine Mummery (Leiden University Medical Center)
Lina Sarro (TU Delft - Electronic Components, Technology and Materials)
More Info
expand_more
Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.
Abstract
We presented the smallest and best characterised EHT devices to date. The devices were fabricated by wafer-scale silicon and polymer processing, characterised by nanoindentation and finite-element simulations, and transferred to 96-well plates for cell seeding and optical tracking of bundle contraction. Cell bundles remained functional for at least 18 days. Pacing electrodes and strain sensors will be added for improved bundle control.