Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions
Bo Yuan (Xi’an Jiaotong University)
Durga Mahor (Xi’an Jiaotong University)
Qiang Fei (Xi’an Jiaotong University)
Ron Wever (Universiteit van Amsterdam)
Miguel Alcalde (Institute of Catalysis, CSIC, Madrid)
Wuyuan Zhang (Xi’an Jiaotong University)
F. Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Peroxyzymes simply use H2O2 as a cosubstrate to oxidize a broad range of inert C-H bonds. The lability of many peroxyzymes against H2O2 can be addressed by a controlled supply of H2O2, ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H2O2 generation. Very promising turnover numbers for the biocatalysts of up to 318 »000 have been achieved.
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