Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane
T. Hilberath (TU Delft - BT/Biocatalysis)
R.J.C. van Oosten (TU Delft - BT/Biocatalysis)
Juliet Victoria (Technical University of Denmark (DTU))
Hugo Brasselet (TU Delft - BT/Biocatalysis)
Miguel Alcalde (Institute of Catalysis, CSIC, Madrid)
John M. Woodley (Technical University of Denmark (DTU))
F. Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Mol-scale oxyfunctionalization of cyclohexane to cyclohexanol/cyclohexanone (KA-oil) using an unspecific peroxygenase is reported. Using AaeUPO from Agrocybe aegerita and simple H2O2 as an oxidant, cyclohexanol concentrations of more than 300 mM (>60% yield) at attractive productivities (157 mM h-1, approx. 15 g L-1 h-1) were achieved. Current limitations of the proposed biooxidation system have been identified paving the way for future improvements and implementation.
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