A Biodegradable, Wireless, Implantable Micropump for Peripheral Nerve Repair
Elena Aprea (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Francesco Stallone (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Feyza Pirim-Aslan (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Leon Abelmann (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Pasqualina M. Sarro (TU Delft - Electrical Engineering, Mathematics and Computer Science)
Clementine Boutry (TU Delft - Electrical Engineering, Mathematics and Computer Science)
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Abstract
Peripheral Nerve Injury (PNI) leads to significant motor and sensory impairments, with limited recovery potential in injuries exceeding 3 cm, Conventional treatments often fail to achieve full functional restoration. Suction-based approaches at lesion sites have demonstrated promising outcomes in nerve regeneration. This work presents a novel wireless, magnetically actuated micropump composed of biodegradable materials, such as poly(octamethylene-maleate(anhydride)citrate) (POMaC), for nerve repair applications. The micropump integrates a magnetic ring within its membrane, enabling deflection under alternating magnetic field (4Hz,pm 150mT), generating a net under-pressure of 1.3 kPa within 8 minutes. It provides a potential solution to facilitate nerve healing.