C.M. Boutry
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10 records found
1
Journal article
(2025)
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J. Bathaei, E.Y. Özüaçıksöz, Z. Liao, M. Yazdan Mehr, Filipe Arroyo Cardoso, C.M. Boutry
The emergence of a new family of wireless biodegradable sensors marks a groundbreaking leap in ecological and environmental sensing. These biodegradable devices can collect a wide range of data in agriculture, climate research, forestry, water management, and biodiversity protection. Manufactured primarily from environmentally safe transient materials for sensing and data transmission, these systems undergo controlled degradation after use, minimizing environmental electronic waste. Here, a critical review of key aspects in the development and application of biodegradable sensors is performed for ecological and environmental monitoring. First, the different materials utilized in the development of biodegradable environmental monitoring devices and their applications are explored. The relevant degradation mechanisms, including hydrolysis, oxidation, photodegradation, and micro-organism action are examined as a function of environmental conditions. Then compatible and non-toxic fabrication techniques are investigated for building biodegradable sensors, emphasizing their scalability and potential for mass production. Finally, system-level considerations are discussed for sustainable powering of these devices, ensuring efficient operation while maintaining environmental sustainability. By surveying a broad spectrum of applications and ongoing advancements, it is argued that biodegradable sensors have a transformative potential in advancing sustainable, widespread, and cost-effective ecological and environmental monitoring solutions.
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The emergence of a new family of wireless biodegradable sensors marks a groundbreaking leap in ecological and environmental sensing. These biodegradable devices can collect a wide range of data in agriculture, climate research, forestry, water management, and biodiversity protection. Manufactured primarily from environmentally safe transient materials for sensing and data transmission, these systems undergo controlled degradation after use, minimizing environmental electronic waste. Here, a critical review of key aspects in the development and application of biodegradable sensors is performed for ecological and environmental monitoring. First, the different materials utilized in the development of biodegradable environmental monitoring devices and their applications are explored. The relevant degradation mechanisms, including hydrolysis, oxidation, photodegradation, and micro-organism action are examined as a function of environmental conditions. Then compatible and non-toxic fabrication techniques are investigated for building biodegradable sensors, emphasizing their scalability and potential for mass production. Finally, system-level considerations are discussed for sustainable powering of these devices, ensuring efficient operation while maintaining environmental sustainability. By surveying a broad spectrum of applications and ongoing advancements, it is argued that biodegradable sensors have a transformative potential in advancing sustainable, widespread, and cost-effective ecological and environmental monitoring solutions.
Conference paper
(2025)
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Elena Aprea, Francesco Stallone, Feyza Pirim-Aslan, Leon Abelmann, Pasqualina M. Sarro, Clementine Boutry
Peripheral Nerve Injury (PNI) leads to significant motor and sensory impairments, with limited recovery potential in injuries exceeding 3 cm, Conventional treatments often fail to achieve full functional restoration. Suction-based approaches at lesion sites have demonstrated promising outcomes in nerve regeneration. This work presents a novel wireless, magnetically actuated micropump composed of biodegradable materials, such as poly(octamethylene-maleate(anhydride)citrate) (POMaC), for nerve repair applications. The micropump integrates a magnetic ring within its membrane, enabling deflection under alternating magnetic field (4Hz,pm 150mT), generating a net under-pressure of 1.3 kPa within 8 minutes. It provides a potential solution to facilitate nerve healing.
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Peripheral Nerve Injury (PNI) leads to significant motor and sensory impairments, with limited recovery potential in injuries exceeding 3 cm, Conventional treatments often fail to achieve full functional restoration. Suction-based approaches at lesion sites have demonstrated promising outcomes in nerve regeneration. This work presents a novel wireless, magnetically actuated micropump composed of biodegradable materials, such as poly(octamethylene-maleate(anhydride)citrate) (POMaC), for nerve repair applications. The micropump integrates a magnetic ring within its membrane, enabling deflection under alternating magnetic field (4Hz,pm 150mT), generating a net under-pressure of 1.3 kPa within 8 minutes. It provides a potential solution to facilitate nerve healing.
Journal article
(2025)
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P. Uliss, H. Gai, F. Kahler, E. Aprea, Q. Jia, Vasiliki Gkouzioti, Jean-Philippe Frimat, E.H. Brück, C.M. Boutry
Magnetothermal stimulation is key in biomedical applications like tumor ablation, drug delivery, and regenerative therapies. A common method involves injecting magnetic particles that heat under an alternating magnetic field (AMF). However, uncontrolled heating can damage healthy tissues. Maintaining temperatures below 45 °C is critical. Using materials with a Curie temperature (Tc) near this limit offers a self-regulating solution, as magnetization—and thus heating—drops sharply at Tc. This study explores Mn0.65Fe1.30P0.65Si0.37 (MCM), a magnetocaloric material composed of non-toxic elements and featuring a tunable Tc. It is engineered to exhibit a Tc of 43 °C, close to the safe physiological threshold. MCM particles are encapsulated in a wax matrix to form a composite that responds to AMF exposure. Heat generated by MCM particles triggers the wax phase transition, while the obtained Tc enables the composite to achieve self-limiting thermal regulation under magnetic field exposure. Biocompatibility tests using human umbilical vein endothelial cells (HUVECs) show over 90% cell viability in direct and indirect contact. Stability tests in phosphate buffers at 37 °C confirm controlled degradation over 28 days. These results demonstrate that MCM is a promising, burn-free magnetic material for safe, localized heating, supporting its use in self-regulating, temperature-responsive biomedical systems.
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Magnetothermal stimulation is key in biomedical applications like tumor ablation, drug delivery, and regenerative therapies. A common method involves injecting magnetic particles that heat under an alternating magnetic field (AMF). However, uncontrolled heating can damage healthy tissues. Maintaining temperatures below 45 °C is critical. Using materials with a Curie temperature (Tc) near this limit offers a self-regulating solution, as magnetization—and thus heating—drops sharply at Tc. This study explores Mn0.65Fe1.30P0.65Si0.37 (MCM), a magnetocaloric material composed of non-toxic elements and featuring a tunable Tc. It is engineered to exhibit a Tc of 43 °C, close to the safe physiological threshold. MCM particles are encapsulated in a wax matrix to form a composite that responds to AMF exposure. Heat generated by MCM particles triggers the wax phase transition, while the obtained Tc enables the composite to achieve self-limiting thermal regulation under magnetic field exposure. Biocompatibility tests using human umbilical vein endothelial cells (HUVECs) show over 90% cell viability in direct and indirect contact. Stability tests in phosphate buffers at 37 °C confirm controlled degradation over 28 days. These results demonstrate that MCM is a promising, burn-free magnetic material for safe, localized heating, supporting its use in self-regulating, temperature-responsive biomedical systems.
Muscle plays a vital role in movement and metabolic regulation, establishing it as a cornerstone of overall health. Monitoring muscular parameters is critical for disease diagnosis, post-surgical recovery, and human–machine interface control. In recent decades, numerous technologies have emerged to monitor muscular biophysical and biochemical processes. The field has transitioned significantly from reliance on large, clinic-bound instrumentation to the development of miniaturized wearable and implantable systems capable of continuous real-time monitoring in everyday settings. This article presents a critical overview of recent advances, with a focus on material and device innovations in muscular monitoring. Starting with the fundamental characteristics of muscle tissue and the physiological origins of biosignals, the discussion subsequently shifts to recent developments in wearable and implantable bioelectronic systems tailored to monitor electrophysiological, biomechanical, and tissue oxygenation signals. Finally, current research challenges and outline emerging opportunities are highlighted in muscular monitoring. Owing to its interdisciplinary nature and growing societal demand for personalized healthcare, muscular monitoring is poised to catalyze transformative innovations in both clinical and consumer applications.
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Muscle plays a vital role in movement and metabolic regulation, establishing it as a cornerstone of overall health. Monitoring muscular parameters is critical for disease diagnosis, post-surgical recovery, and human–machine interface control. In recent decades, numerous technologies have emerged to monitor muscular biophysical and biochemical processes. The field has transitioned significantly from reliance on large, clinic-bound instrumentation to the development of miniaturized wearable and implantable systems capable of continuous real-time monitoring in everyday settings. This article presents a critical overview of recent advances, with a focus on material and device innovations in muscular monitoring. Starting with the fundamental characteristics of muscle tissue and the physiological origins of biosignals, the discussion subsequently shifts to recent developments in wearable and implantable bioelectronic systems tailored to monitor electrophysiological, biomechanical, and tissue oxygenation signals. Finally, current research challenges and outline emerging opportunities are highlighted in muscular monitoring. Owing to its interdisciplinary nature and growing societal demand for personalized healthcare, muscular monitoring is poised to catalyze transformative innovations in both clinical and consumer applications.
Journal article
(2025)
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Mohammad Javad Bathaei, Sina Hashemizadeh, Filipe Arroyo Cardoso, Denys Nikolayev, Clementine M. Boutry
This letter presents the first fabrication and characterization of a biodegradable coaxial cavity resonator, focusing on the measurement of complex permittivity of encapsulation as well as |S11| and impedance parameters. The resonator components are 3D-printed from plant-based resin, coated with silver-coated copper flakes, and enclosed by a laser-cut zinc membrane. A monopole coupler antenna, inspired by the “Great Seal Bug,” is co-designed with the cavity to enable near-field coupling and achieve frequency-selective, near- 50 Ω impedance-matched wireless sensing. Numerical and experimental analysis of the gap between post and membrane (G-post), and between the coupler antenna and post, resulted in| S11 | of −30.3 dB at 1.7 GHz, and a quality factor of 307, outperforming existing flat biodegradable resonators. A 40-MHz resonance shift is observed with a 20 μm variation in G-post, highlighting the resonator’s high sensitivity to membrane position. This system enables battery-free wireless sensing with biodegradable antennas for biodiversity monitoring.
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This letter presents the first fabrication and characterization of a biodegradable coaxial cavity resonator, focusing on the measurement of complex permittivity of encapsulation as well as |S11| and impedance parameters. The resonator components are 3D-printed from plant-based resin, coated with silver-coated copper flakes, and enclosed by a laser-cut zinc membrane. A monopole coupler antenna, inspired by the “Great Seal Bug,” is co-designed with the cavity to enable near-field coupling and achieve frequency-selective, near- 50 Ω impedance-matched wireless sensing. Numerical and experimental analysis of the gap between post and membrane (G-post), and between the coupler antenna and post, resulted in| S11 | of −30.3 dB at 1.7 GHz, and a quality factor of 307, outperforming existing flat biodegradable resonators. A 40-MHz resonance shift is observed with a 20 μm variation in G-post, highlighting the resonator’s high sensitivity to membrane position. This system enables battery-free wireless sensing with biodegradable antennas for biodiversity monitoring.
Meshless Simulation with the Material Point Method
A Micropump for Nerve Injury Treatment
A meshless method is used to simulate the Fluid-Structure Interaction (FSI) in a micropump intended to treat nerve injury. Conventional meshbased methods can suffer from mesh deformation and quality issues, and find it difficult to track the fluid-structure interface. The Material Point Method (MPM) combines Lagrangian material points with an Eulerian computational grid, thereby avoiding any mesh related problems. To simulate the valve dynamics in the micropump, MPM was used to analyze the effect of the valve length on the behaviour of the pump. A longer valve length takes longer to open, as it sticks to the valve seat, meaning the pump needs to generate more pressure to open the valve. This contribution shows that MPM simulations can be used to optimize the valve design for implantable micropumps.
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A meshless method is used to simulate the Fluid-Structure Interaction (FSI) in a micropump intended to treat nerve injury. Conventional meshbased methods can suffer from mesh deformation and quality issues, and find it difficult to track the fluid-structure interface. The Material Point Method (MPM) combines Lagrangian material points with an Eulerian computational grid, thereby avoiding any mesh related problems. To simulate the valve dynamics in the micropump, MPM was used to analyze the effect of the valve length on the behaviour of the pump. A longer valve length takes longer to open, as it sticks to the valve seat, meaning the pump needs to generate more pressure to open the valve. This contribution shows that MPM simulations can be used to optimize the valve design for implantable micropumps.
Poster
(2024)
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E. Aprea, F. Kahler, Marc Vila Cuenca, Mark van der Kroeg, Valeria Orlova, Femke de Vrij, C.M. Boutry
The objective of this review is to investigate the potential of functionalized magnetic polymer composites for use in electromagnetic micro-electro-mechanical systems (MEMS) for biomedical applications. The properties that make magnetic polymer composites particularly interesting for application in the biomedical field are their biocompatibility, their adjustable mechanical, chemical, and magnetic properties, as well as their manufacturing versatility, e.g., by 3D printing or by integration in cleanroom microfabrication processes, which makes them accessible for large-scale production to reach the general public. The review first examines recent advancements in magnetic polymer composites that possess unique features such as self-healing capabilities, shape-memory, and biodegradability. This analysis includes an exploration of the materials and fabrication processes involved in the production of these composites, as well as their potential applications. Subsequently, the review focuses on electromagnetic MEMS for biomedical applications (bioMEMS), including microactuators, micropumps, miniaturized drug delivery systems, microvalves, micromixers, and sensors. The analysis encompasses an examination of the materials and manufacturing processes involved and the specific fields of application for each of these biomedical MEMS devices. Finally, the review discusses missed opportunities and possible synergies in the development of next-generation composite materials and bioMEMS sensors and actuators based on magnetic polymer composites.
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The objective of this review is to investigate the potential of functionalized magnetic polymer composites for use in electromagnetic micro-electro-mechanical systems (MEMS) for biomedical applications. The properties that make magnetic polymer composites particularly interesting for application in the biomedical field are their biocompatibility, their adjustable mechanical, chemical, and magnetic properties, as well as their manufacturing versatility, e.g., by 3D printing or by integration in cleanroom microfabrication processes, which makes them accessible for large-scale production to reach the general public. The review first examines recent advancements in magnetic polymer composites that possess unique features such as self-healing capabilities, shape-memory, and biodegradability. This analysis includes an exploration of the materials and fabrication processes involved in the production of these composites, as well as their potential applications. Subsequently, the review focuses on electromagnetic MEMS for biomedical applications (bioMEMS), including microactuators, micropumps, miniaturized drug delivery systems, microvalves, micromixers, and sensors. The analysis encompasses an examination of the materials and manufacturing processes involved and the specific fields of application for each of these biomedical MEMS devices. Finally, the review discusses missed opportunities and possible synergies in the development of next-generation composite materials and bioMEMS sensors and actuators based on magnetic polymer composites.
Journal article
(2022)
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Sarab S. Sethi, Mirko Kovac, Fabian Wiesemüller, Aslan Miriyev, Clementine M. Boutry
Recent breakthroughs have led to the development of biodegradable sensors which, after collecting data, break down into byproducts that are harmless to their surroundings. Using these sensors to collect ecological data on vast scales and in fine resolution could transform our management and understanding of natural ecosystems.
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Recent breakthroughs have led to the development of biodegradable sensors which, after collecting data, break down into byproducts that are harmless to their surroundings. Using these sensors to collect ecological data on vast scales and in fine resolution could transform our management and understanding of natural ecosystems.