A meshless method is used to simulate the Fluid-Structure Interaction (FSI) in a micropump intended to treat nerve injury. Conventional meshbased methods can suffer from mesh deformation and quality issues, and find it difficult to track the fluid-structure interface. The Material Point Method (MPM) combines Lagrangian material points with an Eulerian computational grid, thereby avoiding any mesh related problems. To simulate the valve dynamics in the micropump, MPM was used to analyze the effect of the valve length on the behaviour of the pump. A longer valve length takes longer to open, as it sticks to the valve seat, meaning the pump needs to generate more pressure to open the valve. This contribution shows that MPM simulations can be used to optimize the valve design for implantable micropumps.

Magnetothermal stimulation is key in biomedical applications like tumor ablation, drug delivery, and regenerative therapies. A common method involves injecting magnetic particles that heat under an alternating magnetic field (AMF). However, uncontrolled heating can damage healthy tissues. Maintaining temperatures below 45 °C is critical. Using materials with a Curie temperature (Tc) near this limit offers a self-regulating solution, as magnetization—and thus heating—drops sharply at Tc. This study explores Mn0.65Fe1.30P0.65Si0.37 (MCM), a magnetocaloric material composed of non-toxic elements and featuring a tunable Tc. It is engineered to exhibit a Tc of 43 °C, close to the safe physiological threshold. MCM particles are encapsulated in a wax matrix to form a composite that responds to AMF exposure. Heat generated by MCM particles triggers the wax phase transition, while the obtained Tc enables the composite to achieve self-limiting thermal regulation under magnetic field exposure. Biocompatibility tests using human umbilical vein endothelial cells (HUVECs) show over 90% cell viability in direct and indirect contact. Stability tests in phosphate buffers at 37 °C confirm controlled degradation over 28 days. These results demonstrate that MCM is a promising, burn-free magnetic material for safe, localized heating, supporting its use in self-regulating, temperature-responsive biomedical systems.