Expanding the Spectrum of Light-Driven Peroxygenase Reactions
Sébastien J.P. Willot (TU Delft - BT/Biocatalysis)
Elena Fernández-Fueyo (TU Delft - BT/Biocatalysis, TU Delft - BN/Greg Bokinsky Lab)
Florian Tieves (TU Delft - BT/Biocatalysis)
Milja Pesic (TU Delft - BT/Biocatalysis)
Miguel Alcalde (Institute of Catalysis, CSIC, Madrid)
Isabel W.C.E. Arends (Universiteit Utrecht)
Chan Beum Park (Korea Advanced Institute of Science and Technology)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Peroxygenases require a controlled supply of H2O2 to operate efficiently. Here, we propose a photocatalytic system for the reductive activation of ambient O2 to produce H2O2 which uses the energy provided by visible light more efficiently based on the combination of wavelength-complementary photosensitizers. This approach was coupled to an enzymatic system to make formate available as a sacrificial electron donor. The scope and current limitations of this approach are reported and discussed.
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