Peroxygenase-Promoted Enzymatic Cascades for the Valorisation of Fatty Acids
Y. Wu (TU Delft - BT/Biocatalysis)
Caroline E. Paul (TU Delft - BT/Biocatalysis)
T. Hilberath (TU Delft - BT/Biocatalysis)
Ewald P.J. Jongkind (TU Delft - BT/Biocatalysis)
Wuyuan Zhang (Chinese Academy of Sciences)
Miguel Alcalde (Instituto de Tecnologías Físicas y de la Información)
F Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Utilisation of fatty acids generally relies on pre-existing functional groups such as the carboxylate group or C=C-double bonds. Addition of new functionalities into the hydrocarbon part opens up new possibilities for fatty acid valorisation. In this contribution we demonstrate the synthetic potential of a peroxygenase mutant AaeUPO−Fett for selective fatty acid oxyfunctionalisation. The ω-1 hydroxy fatty acid (esters) produced are further transformed into lactones, alcohols, esters and amines via multi-enzyme cascades thereby paving the way for new fatty acid valorisation pathways.