Peroxygenase-Promoted Enzymatic Cascades for the Valorisation of Fatty Acids

Journal Article (2023)
Author(s)

Y. Wu (TU Delft - BT/Biocatalysis)

Caroline E. Paul (TU Delft - BT/Biocatalysis)

T. Hilberath (TU Delft - BT/Biocatalysis)

Ewald P.J. Jongkind (TU Delft - BT/Biocatalysis)

Wuyuan Zhang (Chinese Academy of Sciences)

Miguel Alcalde (Instituto de Tecnologías Físicas y de la Información)

F Hollmann (TU Delft - BT/Biocatalysis)

Research Group
BT/Biocatalysis
Copyright
© 2023 Y. Wu, C.E. Paul, T. Hilberath, E.P.J. Jongkind, Wuyuan Zhang, Miguel Alcalde, F. Hollmann
DOI related publication
https://doi.org/10.1002/cctc.202300411
More Info
expand_more
Publication Year
2023
Language
English
Copyright
© 2023 Y. Wu, C.E. Paul, T. Hilberath, E.P.J. Jongkind, Wuyuan Zhang, Miguel Alcalde, F. Hollmann
Research Group
BT/Biocatalysis
Issue number
11
Volume number
15
Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Abstract

Utilisation of fatty acids generally relies on pre-existing functional groups such as the carboxylate group or C=C-double bonds. Addition of new functionalities into the hydrocarbon part opens up new possibilities for fatty acid valorisation. In this contribution we demonstrate the synthetic potential of a peroxygenase mutant AaeUPO−Fett for selective fatty acid oxyfunctionalisation. The ω-1 hydroxy fatty acid (esters) produced are further transformed into lactones, alcohols, esters and amines via multi-enzyme cascades thereby paving the way for new fatty acid valorisation pathways.