A model for controlled dosing of femto-litre volume liquids using hollow microcantilever

Journal article (2017)

Authors

Xi Cao Student
Rick de Gruiter Student
Ralph van Oorschot MA3 Solutions B.V.
S. Baldi Team Bart De Schutter - Mechanical, Maritime and Materials Engineering
S. Hassan HosseinNia Mechatronic Systems Design - Mechanical, Maritime and Materials Engineering
M.K. Ghatkesar Micro and Nano Engineering - Mechanical, Maritime and Materials Engineering
Research Group
Team Bart De Schutter (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: © 2017 Xi Cao, Rick de Gruiter, Ralph van Oorschot, S. Baldi, S. Hassan HosseinNia , M.K. Ghatkesar
DOI: https://doi.org/10.1016/j.ifacol.2017.08.2141
Nanotechnology Dynamic modelling Atomic Force Microscope Femto-liter Hollow-cantilever
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Published Date

2017

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Delft Center for Systems and Control

Research Group

Team Bart De Schutter

Abstract

A hollow microcantilever is used instead of a conventional microcantilever to dispense and aspirate liquids in the femto-litre (10-15 L) volume range in an atomic force microscope (AFM) setup. The inherent force sensing capability of the cantilever is used to monitor the fluid manipulation in-situ. At this small scale, parameters like: surface energy, evaporation, viscosity and temperature become important for controlled manipulation. In a conventional AFM, these parameters are usually not taken into consideration as feedback parameters. In the present work, we report initial experimental results on the dosing process and an analytical dynamic model of the process. The model is based on the liquid bridge between the cantilever tip and the substrate, which can describe the dosing process with variance accounted for (VAF) larger than 90%. We aim to use this model and implement a control system for precise dispensing and aspiration.