MG
Authored
1 records found
On the Use of Black Ti as a Bone Substituting Biomaterial
Behind the Scenes of Dual-Functionality
Despite the potential of small-scale pillars of black titanium (bTi) for killing the bacteria and directing the fate of stem cells, not much is known about the effects of the pillars’ design parameters on their biological properties. Here, three distinct bTi surfaces are desig ...
Contributed
19 records found
High Potential
Design, modelling, and fabrication of a novel unipolar micro-electret transducer
Electret transducers utilize the electric field generated by an electret, a dielectric with a quasi-permanent embedded charge, to induce charge on an electrode. When the electret is moved relative to the electrode, the induced charge magnitude on the electrode changes, generating
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Toward 3D printed suspended microchannel resonators
A study on damping and mass resolution of 3D printed microbeam resonators
Biosensing properties like mass, density and stiffness on a single cell level can help diagnose diseases. Mass sensing of cells and subcellular components is typically performed with resonant microstructures. Recently such microstructures were fabricated using an emerging 3D prin
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Multiscale 3D printed polymer probes for single cell experiments
A rapid prototyping method to fabricate microfluidic atomic force microscopy cantilevers for single cell studies
Facioscapulohumeral muscle dystrophy (FSHD) is the third most common muscle disease in the world. No cure has been found for FSHD, and current treatments focus on alleviating the symptoms. The disease is caused by a genetic error in 1/1000 - 1/200 of the nuclei in a multinuclea
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Liquid dosing on the micro-scale
A quest for increased resolution
The processes that take place within cells are complex. Single-cell analysis is a method that is employed to gain further understanding of the working mechanisms on a single-cellular level. The controlled transport of substances through the cell membrane is important for studying
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Enhancing AFM
Speeding up an AFM measurement by altering the Q factor
The Atomic Force Microscope (afm) is a small scale measuring device, with a lot of benefits over other existing measuring techniques. Unfortunately, measurement speed is not one of them. Many have tried and succeeded to improve the measurement speed, but there is still room for i
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Calcification & Fibrous Tissue Characteristics in Atherosclerotic Plaques
A Combined Analysis and Modeling Approach
Atherosclerotic plaque rupture is the main cause of acute myocardial infarction and stroke, the two leading causes of death worldwide. Rupture of plaque tissue is a mechanical event, where plaque stress or strain locally exceeds its strength. Biomechanical studies agree with hist
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Diamagnetically Levitated Resonant Mass Sensor
Master of Science Thesis
In the past few decades, there has been a growing demand for low-cost disposable sensors to be utilized in hazardous and toxic environments such as high temperature and chemically aggressive environments, which can lead to irreversible damage to the sensor. Moreover, by cost redu
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Design of a valveless organ-on-chip micropump
A new take on on-chip actuation for organ-on-chip devices
In the last few years organ-on-chip (OoC) has been emerging as a new method for more reliable research to screen the effects of new drugs on the body. This is a novel technology mimicking the in vivo environment of tissue cells, making it a more suitable candidate for experimenta
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Photonics biosensors convert biomolecular interactions into quantifiable optical signals for biomedical analysis, which enable continuous monitoring of health indicators. Among them the microring resonator has a good sensing performance and a very broad application prospect. This
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Small satellites require efficient propulsion systems for attitude and orbit control. This thesis focuses on the development and characterization of two distinct types of micro-resistojet thrusters, namely Vaporizing Liquid Micro-resistojet (VLM) and Low Pressure Micro-resistojet
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Single photon detectors are an important optical sensing tool in many industries. However, these highly efficient detectors suffer from variations in the size of an optical cavity when cooling down to 3K. An active positioning system is therefore required to correct the relative
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Much research is conducted on the biomechanical properties of cells, particularly in cancer research. Cell stiffness and cell adhesion are two properties often studied, because they are important for the functioning of a cell. To study these properties, atomic force microscopy(AF
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Life at low-Reynolds numbers regime is intriguing. Single motile bacteria are known to exhibit erratic behaviour; they swim in what is known as a random walk, alternating between periods of swimming straight and abrupt moments of re-orientation. Yet in dense populations, cells of
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A stage heater for inverted optical microscopy was developed as an add-on to TU Delft portable integrated microfluidic platform. The platform was modified to gain additional functionality and portability. The stage heater was designed to work with custom PDMS microfluidic chips a
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The Nobel Prize in Chemistry in 2017 went to the development of cryo-electron microscopy, which contributed to the discovery of new cells and viruses, the diagnosis of unknown diseases, the mapping of human genomes and the manufacturing of semiconductors. Cryo Correlative light a
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Microvalves are important flow-control devices in many standalone and integrated microfluidic applications. PDMS-based (Polydimethylsiloxane) pneumatic microvalves are the most commonly used type for research purposes, but they require large peripheral connections and cannot be u
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Any resonance based sensing method such as AFM or mass sensing using microfluidic cantilevers require high frequency stability. For mass measurement, a stable frequency allows for a lower mass resolution. One of the most commonly used methods to actuate these resonators is using
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Microvalves are useful components for several microfluidic applications in which they control the fluid flow in a microfluidic system. Most microvalves to date are made by using silicon micro-machining, which is a complex manufacturing process, or soft lithography using Polydimet
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Microfluidics has changed the way we think about laboratory experimental design. With the use of lab-on-chip devices, we are capable of carrying out experiments that include several functions on a single chip. Despite a lot of progress in the miniaturization of these devices, the
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