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Towards preparative peroxygenase-catalyzed oxyfunctionalization reactions in organic media

Journal Article (2016)
Author(s)

Elena Fernandez Fueyo (TU Delft - BT/Biocatalysis)

Yan Ni (TU Delft - BT/Biocatalysis)

A. Gomez Baraibar (TU Delft - BT/Biocatalysis)

Miguel Alcalde (University of the Balearic Islands)

LM van Langen (ViaZym)

Frank Hollmann (TU Delft - BT/Biocatalysis)

Research Group
BT/Biocatalysis
Copyright
© 2016 E. Fernandez Fueyo, Y. Ni, A. Gomez Baraibar, Miguel Alcalde, L.M. van Langen, F. Hollmann
DOI related publication
https://doi.org/10.1016/j.molcatb.2016.09.013
More Info
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Publication Year
2016
Language
English
Copyright
© 2016 E. Fernandez Fueyo, Y. Ni, A. Gomez Baraibar, Miguel Alcalde, L.M. van Langen, F. Hollmann
Research Group
BT/Biocatalysis
Volume number
134
Pages (from-to)
347-352
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Abstract

The peroxygenase from Agrocybe aegerita (AaeUPO) has been evaluated for stereoselective oxyfunctionalization chemistry under non-aqueous reaction conditions. The stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol was performed in neat substrate as reaction medium together with the immobilized biocatalyst and tertBuOOH as oxidant. Stability and activity issues still have to be addressed. Nevertheless, gram-scale production of enantiopure (R)-1-phenylethanol was achieved with respectable 90,000 turnovers of the biocatalyst.