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L.M. van Langen

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Multi-catalytic route for the synthesis of (S)-tembamide
Enantiopure β-amino alcohols constitute one of the most significant building blocks for the synthesis of active pharmaceutical ingredients. Despite the availability of a range of chiral β-amino alcohols from a chiral pool, there is a growing demand for new enantioselective synthe ...

Towards preparative peroxygenase-catalyzed oxyfunctionalization reactions in organic media
The peroxygenase from Agrocybe aegerita (AaeUPO) has been evaluated for stereoselective oxyfunctionalization chemistry under non-aqueous reaction conditions. The stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol was performed in neat substrate as reaction mediu ...

Cross-linked enzyme aggregates (CLEAs): A novel and versatile method for enzyme immobilization (a review)

Cross-linked enzyme aggregates (CLEAs): A novel and versatile method for enzyme immobilization (a review)

CLEAs: an effective technique for enzyme immobilisation

Cross-linked enzyme aggregates (CLEAs)

Active site titration as a tool for the evaluation of immobilized pencillin acylase

Active site titration as a tool for the evaluation of immobilized pencillin acylase

A new, mild cross-linking methodology to prepare cross-linked enzyme aggregates

Use of high acyl donor concentrations leads to penicillin acylase inactivation in the course of peptide synthesis

Penicillin acylase catalysed synthesis of ampicillin in hydrophilic organic solvents

Cross-linked aggregates of the hydroxynitrile lyase from Manihot esculenta: highly active and robust biocatalysts

Enzymatic coupling using a mixture of side chain donors affords a greener process for ampicillin.

Penicillin acylase-catalyzed ampicillin synthesis using a pH gradient: a new approach to optimization (niet eerder opgenomen)

Penicillin acylase-catalyzed peptide synthesis in aqueous medium: a chemo-enzymatic route to stereoisomerically pure diketopiperazines

Highly efficient and enantioselective enzymatic acylation of amines in aqueous medium.

Penicillin acylase-catalyzed resolution of amines in aqueous organic solvents.

Cross-linked aggregates of penicillin acylase: robust catalysts for the synthesis of ß-lactam antibiotics.

Biocatalysts and biocatalysis in the synthesis of ß-lactam antibiotics. Chapter 3

Enzymatic hydrocyanation of a sterically hindered aldehyde. Optimization of a chemoenzymatic procedure for (R)-2-chloromandelic acid