Ratiometric analysis of sensor recovery time for organ health monitoring
Avik Sett (TU Delft - Bio-Electronics)
Tanisha Rana (Institute of Engineering and Management)
Robbert Friendwijk (Student TU Delft)
Shaogang Wang (TU Delft - Bio-Electronics)
Massimo Mastrangeli (TU Delft - Electronic Components, Technology and Materials)
Paddy French (TU Delft - Bio-Electronics)
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Abstract
Real-time pH and oxygen concentration sensing is critical for monitoring tissue damage and organ health; however, there is no report to date in such context of a single device that can simultaneously detect both pH and oxygen changes. This paper presents the development of a single optical sensor device that can simultaneously and reversibly respond to changes in both pH and oxygen concentration. The proposed optical sensor integrates both pH- and oxygen-sensitive probes, and is optimized to achieve minimal cross-sensitivity during simultaneous measurements. This approach enables high accuracy in early detection of chemical correlates of tissue or organ damage, improving screening and efficacy in organ transplants.