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Towards Biocatalytic Oxidation of Secondary Alcohols to Carbonyl Products of Relevance for Flavors and Fragrances

Journal Article (2022)
Author(s)

Eva Puchľová (Axxence Slovakia, Bratislava)

T. Hilberath (TU Delft - Applied Sciences)

Kvetoslava Vranková (Axxence Slovakia, Bratislava)

F. Hollmann (TU Delft - Applied Sciences)

Research Group
BT/Biocatalysis
DOI related publication
https://doi.org/10.3389/fctls.2022.926316 Final published version
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Publication Year
2022
Language
English
Research Group
BT/Biocatalysis
Journal title
Frontiers in Catalysis
Volume number
2
Article number
926316
Page Views
294
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Abstract

Non-enantioselective alcohol dehydrogenases (ADHs) are rarely found in the biocatalysis portfolio. Generally, highly enantioselective ADHs are sought for. Using such ADHs for the oxidation of racemic alcohols generally results in a kinetic resolution of the starting material, which is unfavourable if the ketone represents the product of interest. In the current contribution we report the ADH from Sphingobium yanoikuyae (SyADH) as non-enantioselective ADH for the complete oxidation or rac-heptan-2-ol (representing further 2-alkanols).