Print Email Facebook Twitter Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia Title Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia Author Meeter, Lieke H.H. (Erasmus MC) Steketee, Rebecca M.E. (Erasmus MC) Salkovic, Dina (Erasmus MC) Vos, Maartje E. (Erasmus MC) Grossman, Murray (University of Pennsylvania) McMillan, Corey T. (University of Pennsylvania) Niessen, W.J. (TU Delft ImPhys/Quantitative Imaging; Erasmus MC) Papma, Janne M. (Erasmus MC) De Jong, Frank Jan (Erasmus MC) Date 2019 Abstract Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. Methods: This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset). Results: CSF NfL levels were significantly higher in patients with SD (median: 2326 pg/mL, IQR: 1628-3593) than in controls (577 (446-766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs=-0.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs=-0.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival. Conclusion: CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities. To reference this document use: http://resolver.tudelft.nl/uuid:19a08116-c729-4ef6-9a1d-34b55aabdfc9 DOI https://doi.org/10.1136/jnnp-2018-319784 ISSN 0022-3050 Source Journal of Neurology, Neurosurgery and Psychiatry, 90 (9), 997-1004 Part of collection Institutional Repository Document type journal article Rights © 2019 Lieke H.H. Meeter, Rebecca M.E. Steketee, Dina Salkovic, Maartje E. Vos, Murray Grossman, Corey T. McMillan, W.J. Niessen, Janne M. Papma, Frank Jan De Jong, More Authors Files PDF p22_molina.pdf 1.71 MB Close viewer /islandora/object/uuid:19a08116-c729-4ef6-9a1d-34b55aabdfc9/datastream/OBJ/view