Print Email Facebook Twitter Brain maturation of the adolescent rat cortex and striatum: Changes in volume and myelination Title Brain maturation of the adolescent rat cortex and striatum: Changes in volume and myelination Author Mengler, L. Khmelinskii, A. Diedenhofen, M. Po, C. Staring, M. Lelieveldt, B.P.F. Hoehn, M. Faculty Electrical Engineering, Mathematics and Computer Science Department Intelligent Systems Date 2013-08-27 Abstract Longitudinal studies on brain pathology and assessment of therapeutic strategies rely on a fully mature adult brain to exclude confounds of cerebral developmental changes. Thus, knowledge about onset of adulthood is indispensable for discrimination of developmental phase and adulthood. We have performed a high-resolution longitudinal MRI study at 11.7 T of male Wistar rats between 21 days and six months of age, characterizing cerebral volume changes and tissue-specific myelination as a function of age. Cortical thickness reaches final value at 1 month, while volume increases of cortex, striatum and whole brain end only after two months. Myelin accretion is pronounced until the end of the third postnatal month. After this time, continuing myelination increases in cortex are still seen on histological analysis but are no longer reliably detectable with diffusion-weighted MRI due to parallel tissue restructuring processes. In conclusion, cerebral development continues over the first three months of age. This is of relevance for future studies on brain disease models which should not start before the end of month 3 to exclude serious confounds of continuing tissue development. Subject brain developmentage-dependent T2 relaxation changesage-dependent diffusion changesmyelination maturationtissue restructuring during cerebral developmentvolume changes of cerebral structures during development To reference this document use: http://resolver.tudelft.nl/uuid:28cb9ab4-4f3b-4f35-931c-7eb54d1ee556 DOI https://doi.org/10.1016/j.neuroimage.2013.08.034 Publisher Elsevier ISSN 1053-8119 Source NeuroImage, 84, 2014 Part of collection Institutional Repository Document type journal article Rights © 2013 The Author(s)This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Files PDF Lelieveldt_2013.pdf 3.12 MB Close viewer /islandora/object/uuid:28cb9ab4-4f3b-4f35-931c-7eb54d1ee556/datastream/OBJ/view