Print Email Facebook Twitter Determinants of carotid atherosclerotic plaque burden in a stroke-free population Title Determinants of carotid atherosclerotic plaque burden in a stroke-free population Author Selwaness, Mariana (Erasmus MC) Hameeteman, Reinhard (Erasmus MC) Van 't Klooster, Ronald (Leiden University Medical Center) Van den Bouwhuijsen, Quirijn (Erasmus MC) Hofman, Albert (Erasmus MC) Franco, Oscar H. (Erasmus MC) Niessen, W.J. (TU Delft ImPhys/Quantitative Imaging; Erasmus MC) Klein, Stefan (Erasmus MC) Vernooij, Meike W. (Erasmus MC) Van der Lugt, Aad (Erasmus MC) Wentzel, Jolanda J. (Erasmus MC) Date 2016-12-01 Abstract Background and aims In a large stroke-free population, we sought to identify cardiovascular risk factors and carotid plaque components associated with carotid plaque burden, lumen volume and stenosis. Methods The carotid arteries of 1562 stroke-free participants from The Rotterdam Study were imaged on a 1.5-Tesla MRI scanner. Inner and outer wall of the carotid arteries were automatically segmented and lumen volume (mm3), wall volume (outer wall–inner wall) and plaque burden (wall volume/outer wall volume) (%) were quantified. Plaque components were visually determined and luminal stenosis was assessed. We analyzed associations of cardiovascular risk factors and carotid plaque components with plaque burden and lumen volumes using regression analysis. Results We investigated 2821 carotid plaques and found that women had larger plaque burden (50.7 ± 7.8% vs. 49.2 ± 7.7%, p <0.0001) and smaller lumen volumes (933 ± 286 mm3 vs. 1078 ± 334 mm3, p <0.0001) than men. In women, age, HDL-cholesterol and systolic blood pressure, and in men, total cholesterol, non-HDL cholesterol and statin use were independently associated with higher plaque burden and lumen volume. Furthermore, smoking and diabetes were associated with lumen volume in men (respectively p = 0.04 and p = 0.002). Intraplaque hemorrhage (IPH) and lipid were related to a larger plaque burden (OR 1.30 [1.05–1.60] and OR 1.28[1.06–1.55]). Finally, within the highest quartile of plaque burden, IPH was strongly associated with luminal stenosis independent of age, sex, plaque burden and composition (Beta = 15.2; [11.8–18.6]). Conclusions Several cardiovascular risk factors and plaque components, in particular IPH, are associated with higher plaque burden. Carotid IPH is strongly associated with an increased luminal stenosis. Subject AtherosclerosisAutomated segmentationCarotid arteryMagnetic resonance imagingPlaque burdenPlaque volume To reference this document use: http://resolver.tudelft.nl/uuid:2f09d5f3-1d85-4566-aa49-0e390d0866a1 DOI https://doi.org/10.1016/j.atherosclerosis.2016.10.030 ISSN 0021-9150 Source Atherosclerosis, 255, 186-192 Part of collection Institutional Repository Document type journal article Rights © 2016 Mariana Selwaness, Reinhard Hameeteman, Ronald Van 't Klooster, Quirijn Van den Bouwhuijsen, Albert Hofman, Oscar H. Franco, W.J. Niessen, Stefan Klein, Meike W. Vernooij, Aad Van der Lugt, Jolanda J. Wentzel Files PDF 1_s2.0_S0021915016314332_main.pdf 447.88 KB Close viewer /islandora/object/uuid:2f09d5f3-1d85-4566-aa49-0e390d0866a1/datastream/OBJ/view