Print Email Facebook Twitter Intraoperative tumor margin assessment using diffuse reflectance spectroscopy Title Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: The effect of electrosurgery on tissue discrimination using ex vivo animal tissue models Author Azizian Amiri, S. (TU Delft Medical Instruments & Bio-Inspired Technology) van Gent, Carlijn M. (Student TU Delft) Dankelman, J. (TU Delft Medical Instruments & Bio-Inspired Technology) Hendriks, B.H.W. (TU Delft Medical Instruments & Bio-Inspired Technology; Philips Research) Date 2020 Abstract Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance of an electrosurgical knife integrated with a DRS on porcine muscle and adipose tissue. Characterization of the formed debris on the optical fibers after electrosurgery revealed that the contamination is mostly burned tissue. Even with contaminated optical fibers, both tissues could still be discriminated with DRS based on fat/water ratio. Therefore, an electrosurgical knife integrated with DRS may be a promising technology to provide the surgeon with real-time guidance during BCS. To reference this document use: http://resolver.tudelft.nl/uuid:566f2228-f10f-40c0-bd35-9f9cce77e2f7 DOI https://doi.org/10.1364/BOE.385621 ISSN 2156-7085 Source Biomedical Optics Express, 11 (5), 2402-2415 Part of collection Institutional Repository Document type journal article Rights © 2020 S. Azizian Amiri, Carlijn M. van Gent, J. Dankelman, B.H.W. Hendriks Files PDF boe_11_5_2402.pdf 4.01 MB Close viewer /islandora/object/uuid:566f2228-f10f-40c0-bd35-9f9cce77e2f7/datastream/OBJ/view