Print Email Facebook Twitter Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography Title Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography Author Ren, Wuwei (University Hospital Zürich; University of Zürich) Jiang, Jingjing (University Hospital Zürich) Di Costanzo Mata, Aldo (University Hospital Zürich) Kalyanov, Alexander (University Hospital Zürich) Ripoll, Jorge (Carlos III University of Madrid; Instituto de Investigación Sanitaria Gregorio Marañón) Lindner, S.A. (TU Delft (OLD)Applied Quantum Architectures; University Hospital Zürich; Swiss Federal Institute of Technology) Charbon-Iwasaki-Charbon, E. (TU Delft (OLD)Applied Quantum Architectures; TU Delft OLD QCD/Charbon Lab; Swiss Federal Institute of Technology) Zhang, C. (TU Delft QN/High Resolution Electron Microscopy) Rudin, Markus (University of Zürich) Wolf, Martin (University Hospital Zürich) Date 2020-03-30 Abstract Fluorescence molecular tomography (FMT) emerges as a powerful non-invasive imaging tool with the ability to resolve fluorescence signals from sources located deep in living tissues. Yet, the accuracy of FMT reconstruction depends on the deviation of the assumed optical properties from the actual values. In this work, we improved the accuracy of the initial optical properties required for FMT using a new-generation time-domain (TD) near-infrared optical tomography (NIROT) system, which effectively decouples scattering and absorption coefficients. We proposed a multimodal paradigm combining TD-NIROT and continuous-wave (CW) FMT. Both numerical simulation and experiments were performed on a heterogeneous phantom containing a fluorescent inclusion. The results demonstrate significant improvement in the FMT reconstruction by taking the NIROT-derived optical properties as prior information. The multimodal method is attractive for preclinical studies and tumor diagnostics since both functional and molecular information can be obtained. To reference this document use: http://resolver.tudelft.nl/uuid:8508a4e8-53cc-4f59-9697-ab9e697bb211 DOI https://doi.org/10.1364/OE.385392 ISSN 1094-4087 Source Optics Express, 28 (7), 9860-9874 Part of collection Institutional Repository Document type journal article Rights © 2020 Wuwei Ren, Jingjing Jiang, Aldo Di Costanzo Mata, Alexander Kalyanov, Jorge Ripoll, S.A. Lindner, E. Charbon-Iwasaki-Charbon, C. Zhang, Markus Rudin, Martin Wolf Files PDF oe_28_7_9860.pdf 3.65 MB Close viewer /islandora/object/uuid:8508a4e8-53cc-4f59-9697-ab9e697bb211/datastream/OBJ/view