Print Email Facebook Twitter A Parametric 3D Model of Human Airways for Particle Drug Delivery and Deposition Title A Parametric 3D Model of Human Airways for Particle Drug Delivery and Deposition Author Geronzi, Leonardo (University of Rome Tor Vergata; RBF Morph, Rome) Fanni, Benigno Marco (Bioengineering Unit, Massa) De Jong, Bart (ONE Simulations, Leiden) Roest, G.T.H. (Grep IT, Noordwijkerhout) Kenjeres, S. (TU Delft ChemE/Transport Phenomena) Celi, Simona (Bioengineering Unit, Massa) Biancolini, Marco Evangelos (University of Rome Tor Vergata; RBF Morph, Rome) Date 2024 Abstract The treatment for asthma and chronic obstructive pulmonary disease relies on forced inhalation of drug particles. Their distribution is essential for maximizing the outcomes. Patient-specific computational fluid dynamics (CFD) simulations can be used to optimize these therapies. In this regard, this study focuses on creating a parametric model of the human respiratory tract from which synthetic anatomies for particle deposition analysis through CFD simulation could be derived. A baseline geometry up to the fourth generation of bronchioles was extracted from a CT dataset. Radial basis function (RBF) mesh morphing acting on a dedicated tree structure was used to modify this baseline mesh, extracting 1000 synthetic anatomies. A total of 26 geometrical parameters affecting branch lengths, angles, and diameters were controlled. Morphed models underwent CFD simulations to analyze airflow and particle dynamics. Mesh morphing was crucial in generating high-quality computational grids, with 96% of the synthetic database being immediately suitable for accurate CFD simulations. Variations in wall shear stress, particle accretion rate, and turbulent kinetic energy across different anatomies highlighted the impact of the anatomical shape on drug delivery and deposition. The study successfully demonstrates the potential of tree-structure-based RBF mesh morphing in generating parametric airways for drug delivery studies. Subject computational fluid dynamicsparametric airways modelingparticle depositionRBF mesh morphingrespiratory diseases To reference this document use: http://resolver.tudelft.nl/uuid:be422b2d-28a0-4205-836b-231ff3d8c850 DOI https://doi.org/10.3390/fluids9010027 ISSN 2311-5521 Source Fluids, 9 (1) Part of collection Institutional Repository Document type journal article Rights © 2024 Leonardo Geronzi, Benigno Marco Fanni, Bart De Jong, G.T.H. Roest, S. Kenjeres, Simona Celi, Marco Evangelos Biancolini Files PDF fluids-09-00027.pdf 2.53 MB Close viewer /islandora/object/uuid:be422b2d-28a0-4205-836b-231ff3d8c850/datastream/OBJ/view