Print Email Facebook Twitter High-definition imaging of carotid artery wall dynamics Title High-definition imaging of carotid artery wall dynamics Author Kruizinga, P. (Erasmus MC) Mastik, Frits (Erasmus MC) van den Oord, Stijn C.H. (Erasmus MC) Schinkel, Arend F.L. (Erasmus MC) Bosch, Johannes G. (Erasmus MC) de Jong, N. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC; Interuniversity Cardiology Institute of the Netherlands) van Soest, G. (Erasmus MC) van der Steen, A.F.W. (TU Delft ImPhys/Acoustical Wavefield Imaging; Erasmus MC; Chinese Academy of Sciences; Interuniversity Cardiology Institute of the Netherlands) Date 2014 Abstract The carotid artery (CA) is central to cardiovascular research, because of the clinical relevance of CA plaques as culprits of stroke and the accessibility of the CA for cardiovascular screening. The viscoelastic state of this artery, essential for clinical evaluation, can be assessed by observing arterial deformation in response to the pressure changes throughout the cardiac cycle. Ultrasound imaging has proven to be an excellent tool to monitor these dynamic deformation processes. We describe how a new technique called high-frame-rate ultrasound imaging captures the tissue deformation dynamics throughout the cardiac cycle in unprecedented detail. Local tissue motion exhibits distinct features of sub-micrometer displacements on a sub-millisecond time scale. We present a high-definition motion analysis technique based on plane wave ultrasound imaging able to capture these features. We validated this method by screening a group of healthy volunteers and compared the results with those for two patients known to have atherosclerosis to illustrate the potential utility of this technique. Subject Carotid arteryHigh-frame-rate ultrasoundPlane wave imagingPulse wave velocityTissue Doppler To reference this document use: http://resolver.tudelft.nl/uuid:c21d8633-397b-4ba8-95d4-bcbb4fa79f80 DOI https://doi.org/10.1016/j.ultrasmedbio.2014.03.009 Embargo date 2015-10-01 ISSN 0301-5629 Source Ultrasound in Medicine & Biology, 40 (10), 2392-2403 Part of collection Institutional Repository Document type journal article Rights © 2014 P. Kruizinga, Frits Mastik, Stijn C.H. van den Oord, Arend F.L. Schinkel, Johannes G. Bosch, N. de Jong, G. van Soest, A.F.W. van der Steen Files PDF 1_s2.0_S0301562914001574_main.pdf 3.54 MB Close viewer /islandora/object/uuid:c21d8633-397b-4ba8-95d4-bcbb4fa79f80/datastream/OBJ/view