Print Email Facebook Twitter On the magnetic nanoparticle injection strategy for hyperthermia treatment Title On the magnetic nanoparticle injection strategy for hyperthermia treatment Author Jiang, Qian (The Hong Kong Polytechnic University) Ren, Feng (The Hong Kong Polytechnic University; Northwestern Polytechnical University) Wang, Chenglei (The Hong Kong Polytechnic University) Wang, Zhaokun (The Hong Kong Polytechnic University) Kefayati, Gholamreza (University of Tasmania) Kenjeres, S. (TU Delft ChemE/Transport Phenomena) Vafai, Kambiz (University of California) Liu, Yang (The Hong Kong Polytechnic University) Tang, Hui (The Hong Kong Polytechnic University) Date 2022 Abstract We developed a dedicated computational framework by coupling the lattice-Boltzmann-method (LBM) modeling and the particle-swarm-optimization (PSO) algorithm to search optimal strategies of magnetic nanoparticle (MNP) injection for hyperthermia-based cancer treatment. Two simplified tumor models were considered: a circular model representing geometrically regular tumors and an elliptic model representing geometrically irregular tumors, both sharing the same area. The temperature distribution in the tumor and its surrounding healthy tissue was predicted by solving the Pennes’ bio-heat transfer equation (PBHTE). Both single- and multi-site injection strategies were explored. The results suggest that the multi-site injection strategies generally work well, while the single-site injection strategy fails even on the simplest circular tumor model. The more the injection sites, the better the performance. In particular, when the number of injection sites reaches eight, all temperature requirements can be nearly 100% satisfied in both tumor models. Whether or not including the minimum dose requirement in the objective function only affects the optimization results by less than 2%. The thermal dose was also assessed by considering both temperature and heat exposure time. It was found that the optimal multi-site injection strategies perform reasonably well for both tumor models. Although the setting is only two dimensional and the optimization is on very simplified tumor models, the framework adopted in this present study works well and can provide useful insights into magnetic hyperthermia treatment. Subject Lattice Boltzmann methodMagnetic hyperthermia treatmentMagnetic nanoparticleParticle swarm optimization To reference this document use: http://resolver.tudelft.nl/uuid:d0be1bbc-2a43-4b2f-9db8-cd05a1a1e8a3 DOI https://doi.org/10.1016/j.ijmecsci.2022.107707 Embargo date 2023-07-01 ISSN 0020-7403 Source International Journal of Mechanical Sciences, 235 Bibliographical note Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public. Part of collection Institutional Repository Document type journal article Rights © 2022 Qian Jiang, Feng Ren, Chenglei Wang, Zhaokun Wang, Gholamreza Kefayati, S. Kenjeres, Kambiz Vafai, Yang Liu, Hui Tang Files PDF 1_s2.0_S0020740322005872_main.pdf 3.69 MB Close viewer /islandora/object/uuid:d0be1bbc-2a43-4b2f-9db8-cd05a1a1e8a3/datastream/OBJ/view