Print Email Facebook Twitter Industrial relevance of chromosomal copy number variation in Saccharomyces yeasts Title Industrial relevance of chromosomal copy number variation in Saccharomyces yeasts Author Gorter de Vries, A.R. (TU Delft BT/Industriele Microbiologie) Pronk, J.T. (TU Delft BT/Industriele Microbiologie) Daran, J.G. (TU Delft BT/Industriele Microbiologie) Date 2017-06-01 Abstract Chromosomal copy number variation (CCNV) plays a key role in evolution and health of eukaryotes. The unicellular yeast Saccharomyces cerevisiae is an important model for studying the generation, physiological impact, and evolutionary significance of CCNV. Fundamental studies of this yeast have contributed to an extensive set of methods for analyzing and introducing CCNV. Moreover, these studies provided insight into the balance between negative and positive impacts of CCNV in evolutionary contexts. A growing body of evidence indicates that CCNV not only frequently occurs in industrial strains of Saccharomyces yeasts but also is a key contributor to the diversity of industrially relevant traits. This notion is further supported by the frequent involvement of CCNV in industrially relevant traits acquired during evolutionary engineering. This review describes recent developments in genome sequencing and genome editing techniques and discusses how these offer opportunities to unravel contributions of CCNV in industrial Saccharomyces strains as well as to rationally engineer yeast chromosomal copy numbers and karyotypes. Subject AneuploidyEvolutionary adaptationFermentationGenome engineeringIndustrial yeastIndustrial yeast fermentationStrain improvement To reference this document use: http://resolver.tudelft.nl/uuid:72090752-81c2-44c1-a068-d329785f24fd DOI https://doi.org/10.1128/AEM.03206-16 ISSN 0099-2240 Source Applied and Environmental Microbiology, 83 (11) Part of collection Institutional Repository Document type journal article Rights © 2017 A.R. Gorter de Vries, J.T. Pronk, J.G. Daran Files PDF Appl._Environ._Microbiol. ... Vries_.pdf 1.44 MB Close viewer /islandora/object/uuid:72090752-81c2-44c1-a068-d329785f24fd/datastream/OBJ/view