Search results | TU Delft Repositories

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The AccelerAge framework: a new statistical approach to predict biological age based on time-to-event data

Sluiskes, Marije (author), Goeman, Jelle (author), Beekman, Marian (author), Slagboom, Eline (author), van den Akker, E.B. (author), Putter, H. (author), Rodríguez-Girondo, Mar (author)

Aging is a multifaceted and intricate physiological process characterized by a gradual decline in functional capacity, leading to increased susceptibility to diseases and mortality. While chronological age serves as a strong risk factor for age-related health conditions, considerable heterogeneity exists in the aging trajectories of...

journal article 2024

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Dynamic characteristics of skin reaction force in different body postures

Marsidi, Nick (author), Scheepens, Karlijn M.J. (author), Goeman, Jelle J. (author), Horeman, T. (author), Genders, Roel E. (author)

Mechanical stress influences scarring of a surgical wound. Several lines have been proposed for the best excision direction. It is unknown if these lines still apply when the body posture changes. The objective is to measure the skin reaction force in four directions and determine the direction of least force. Secondary objective is to...

journal article 2023

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Development of a maturity model for blended education: A delphi study

Goeman, Katie (author), Dijkstra, W.P. (author), Poelmans, Stephan (author), Vemuri, Pavani (author), van Valkenburg, W.F. (author)

In order to embed blended learning environments in a strategic and sustainable manner, a multi-actor, multidimensional approach is necessary. This paper reports the results of a 3-round Delphi study involving 28 experts which focuses on the refinement and validation of a layered maturity model that assesses key aspects of blended practices in...

journal article 2021

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Echo planar imaging–induced errors in intracardiac 4D flow MRI quantification

Westenberg, Jos J.M. (author), van Assen, Hans C. (author), van den Boogaard, Pieter J. (author), Goeman, Jelle J. (author), Saaid, Hicham (author), Voorneveld, J.D. (author), Bosch, Johan (author), Kenjeres, S. (author), Claessens, Tom (author)

Purpose: To assess errors associated with EPI-accelerated intracardiac 4D flow MRI (4DEPI) with EPI factor 5, compared with non-EPI gradient echo (4DGRE). Methods: Three 3T MRI experiments were performed comparing 4DEPI to 4DGRE: steady flow through straight tubes, pulsatile flow in a left-ventricle phantom, and intracardiac flow in 10...

journal article 2021

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Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging

Van den Akker, E.B. (author), Passtoors, W.M. (author), Jansen, R. (author), Van Zwet, E.W. (author), Goeman, J.J. (author), Hulsman, M. (author), Emilsson, V. (author), Perola, M. (author), Willemsen, G. (author), Penninx, B.W.J.H. (author), Heijmans, B.T. (author), Maier, A.B. (author), Boomsma, D.I. (author), Kok, J.N. (author), Slagboom, P.E. (author), Reinders, M.J.T. (author), Beekman, M. (author)

The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approach for combining multiple...

journal article 2013

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Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

Slieker, R.C. (author), Bos, S.D. (author), Goeman, J.J. (author), Bovee, J.V.M.G. (author), Talens, R.P. (author), Van der Breggen, R. (author), Suchiman, H.E.D. (author), Lameijer, E.W. (author), Putter, H. (author), Van dern Akker, E.B. (author), Zhang, Y. (author), Jukema, J.W. (author), Slagboom, P.E. (author), Meulenbelt, I. (author), Heijmans, B.T. (author)

Background: DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated genomic regions, but due to differences in study design and focus there still is no consensus as to the annotation of genomic regions predominantly involved in tissue-specific...

journal article 2013

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Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

Passtoors, W.M. (author), Boer, J.M. (author), Goeman, J.G. (author), Van den Akker, E.B. (author), Deelen, J. (author), Zwaan, B.J. (author), Scarborough, A. (author), Van der Breggen, R. (author), Vossen, R.H.A.M. (author)

The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for...

journal article 2012

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Practicum mt513p Scheepsbewegingen

Goeman, Alex (author)

report 1998

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De bepaling van zwaartepuntsligging en massatraagheidsmomenten van een scheeps-model

Goeman, Alex (author)

report 1998

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Practicum mt512p Weerstand en Voortstuwing

Goeman, Alex (author)